RT Dissertation/Thesis
T1 Epigenomic characterization of circulating tumour cells in advanced colorectal cancer
A1 Bao Caamaño, Aida
K1 Colorectal cancer
K1 Epigenetics
K1 DNA methylation
K1 Liquid biopsy
K1 Circulating tumour cells
K1 Biomarkers
K1 Therapeutic targets
AB Metastatic colorectal cancer continues to be a major health burden despiteadvances in detection and therapy. Molecular characterization of circulating tumour cells (CTCs), main drivers ofthe metastatic process, and the study of epigenetic mechanisms hold great promise to identify new targets for drugdevelopment and biomarkers to assess therapy response. In this frame, this thesis characterized the DNAmethylome of CTCs in advanced colorectal cancer, providing new information about the biology of these cells andthe metastatic process. This study also identified new potential therapeutic targets and epigenetic biomarkers thatcould help guide therapeutic decisions in patients with advanced disease, contributing to achieve a morepersonalized medicine in colorectal cancer.
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30708
UL http://hdl.handle.net/10347/30708
LA eng
DS Minerva
RD 23 abr 2026