RT Journal Article
T1 Poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: synthesis and post-polymerisation modification
A1 Crisan, Daniel
A1 Creese, Oliver
A1 Brioso, Jose Luis
A1 Montenegro García, Javier
A1 Fernández Trillo, Francisco
AB Here we present the synthesis and post-polymerisation modification of poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: poly(acryloyl hydrazide) was prepared from commercially available starting materials in a three step synthesis on a large scale, in good yields and high purity. Our synthetic approach included the synthesis of a Boc-protected acryloyl hydrazide, the preparation of polymers via RAFT polymerisation and the deprotection of the corresponding Boc-protected poly(acryloyl hydrazide). Post-polymerisation modification of poly(acryloyl hydrazide) was then demonstrated using a range of conditions for both hydrophilic and hydrophobic aldehydes. These experiments demonstrate the potential of poly(acryloyl hydrazide) as a scaffold in the synthesis of functional polymers, in particular those applications where in situ screening of the activity of the functionalised polymers may be required (e.g. biological applications)
PB Royal Society of Chemistry
YR 2017
FD 2017
LK http://hdl.handle.net/10347/21408
UL http://hdl.handle.net/10347/21408
LA eng
NO Crisan, D., Creese, O., Ball, R., Brioso, J., Martyn, B., Montenegro, J., & Fernandez-Trillo, F. (2017). Poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: synthesis and post-polymerisation modification. Polymer Chemistry, 8(31), 4576-4584. doi: 10.1039/c7py00535k
NO This work was supported by the Royal Society, U.K (IE130688) and the Wellcome Trust (177ISSFPP). F. F.-T. thanks the Birmingham Science City and the European Regional Development Fund, the Royal Society (RG140273), and the University of Birmingham (John Evans Fellowship). J. M. thanks funding from MINECO (CTQ2014-59646-R, RYC-2013-1378) the Xunta de Galicia (ED431G/09 and 2016-AD031) and the ERC (Stg-DYNAP-677786)
DS Minerva
RD 24 abr 2026