RT Journal Article
T1 Ruthenium-catalyzed intermolecular alkene–alkyne couplings in biologically relevant media
A1 Gutiérrez González, Alejandro
A1 Marcos-Atanes, Daniel
A1 Cool, Leonard G.
A1 López García, Fernando José
A1 Mascareñas Cid, José Luis
AB Cationic cyclopentadienyl Ru(II) catalysts can efficiently promote mild intermolecular alkyne–alkene couplings in aqueous media, even in the presence of different biomolecular components, and in complex media like DMEM. The method can also be used for the derivatization of amino acids and peptides, therefore proposing a new way to label biomolecules with external tags. This C–C bond-forming reaction, based on simple alkene and alkyne reactants, can now be added to the toolbox of bioorthogonal reactions promoted by transition metal catalysts
PB Royal Society of Chemistry
SN 1478-6524
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30683
UL http://hdl.handle.net/10347/30683
LA eng
NO Chem. Sci., 2023, 14, 6408
NO This work has received financial support from Spanish grants (Grants PID2020-118579GB-I00 and PID2019-108624RB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”, and ORFEO-CINQA network RED2018-102387-T), the Consellería de Cultura, Educación e Ordenación Universitaria (Grant ED431C 2021/25 and Grant ED431G 2019/03: Centro Singular de Investigación de Galicia accreditation 2019–2022) and the European Union (European Regional Development Fund-ERDF corresponding to the multiannual financial framework 2014–2020). We thank the Ministerio de Universidades for the FPU fellowship to A. G. and D. M.-A. (FPU17/00711 and FPU18/04495)
DS Minerva
RD 29 abr 2026