RT Journal Article
T1 Alterations in functional connectivity in individuals with subjective cognitive decline and hippocampal atrophy
A1 Varela-López, Benxamín
A1 Rivas Fernández, Miguel Ángel
A1 Zurrón Ocio, Montserrat
A1 Lindín Novo, Mónica
A1 Díaz Fernández, Fernando
A1 Galdo Álvarez, Santiago
K1 Default-mode network
K1 Hippocampus
K1 Subjective cognitive decline
K1 Task-positive networks
K1 Resting-state
K1 FMRI
K1 Alzheimer’s Disease
K1 Dementia
AB ObjectivesThe aim of this study was to determine whether individuals with Subjective Cognitive Decline (SCD), particularly those with a neurostructural marker of risk for AD (SCD+), exhibit differences in the functional connectivity of the Default-Mode Network (DMN) relative to controls, as this network is known to be altered in the AD continuum.DesignCross-sectional study.SettingGalicia, Northwest Spain.ParticipantsThe sample compromised 133 participants: 69 controls, 51 SCD and 13 SCD+.MeasurementsSeed-to-voxel analysis was conducted using four DMN ROIs. Dynamic independent component analysis of the DMN was also performed.ResultsThe SCD and SCD+ groups exhibited DMN hyperconnectivity, which was more extensive in the SCD+ group. Increased anti-correlations between DMN and task-positive parietal regions were related to poorer executive scores in SCD+ and a tendency for higher DMN recurrence in SCD+.ConclusionsHippocampal atrophy as a SCD+ biomarker is associated with extensive DMN hyperconnectivity and increased anti-correlations between DMN and task-positive network regions.
PB Elsevier
SN 1041-6102
YR 2025
FD 2025-03-31
LK https://hdl.handle.net/10347/41794
UL https://hdl.handle.net/10347/41794
LA eng
NO International Psychogeriatrics Available online 31 March 2025, 100067
NO This work was supported by grants from the Spanish Government, Ministerio de Economía y Competitividad (PSI2014–55316-C3–3-R; PSI2017–89389-C2–2-R; and PID2020–114521RB-C21/C22) and the Galician Government, Axudas para a Consolidación e Estruturación de Unidades de Investigación Competitivas do Sistema Universitario de Galicia: GRC (GI-1807-USC. Ref: ED431–2017/27 and ED431C-2021/04). All with ERDF/FEDER funds. The first author is grateful for a pre-doctoral fellowship awarded by the Galician Government (Xunta de Galicia, Consellería de Cultura, Educación, Formación Profesional e Universidades, Ref. ED481A).
DS Minerva
RD 24 abr 2026