RT Journal Article
T1 Supramolecular fibrillation of peptide amphiphiles induces environmental responses in aqueous droplets
A1 Booth, Richard
A1 Insua López, Ignacio
A1 Ahmed, Sahnawaz
A1 Rioboo Vidal, Alicia
A1 Montenegro García, Javier
K1 Self-assembly
K1 Supramolecular polymers
AB One-dimensional (1D) supramolecular polymers are commonly found in natural and synthetic systems to prompt functional responses that capitalise on hierarchical molecular ordering. Despite amphiphilic self-assembly being significantly studied in the context of aqueous encapsulation and autopoiesis, very little is currently known about the physico-chemical consequences and functional role of 1D supramolecular polymerisation confined in aqueous compartments. Here, we describe the different phenomena that resulted from the chemically triggered supramolecular fibrillation of synthetic peptide amphiphiles inside water microdroplets. The confined connection of suitable dormant precursors triggered a physically autocatalysed chemical reaction that resulted in functional environmental responses such as molecular uptake, fusion and chemical exchange. These results demonstrate the potential of minimalistic 1D supramolecular polymerisation to modulate the behaviour of individual aqueous entities with their environment and within communities
PB Nature
SN 2041-1723
YR 2021
FD 2021
LK http://hdl.handle.net/10347/30329
UL http://hdl.handle.net/10347/30329
LA eng
NO Booth, R., Insua, I., Ahmed, S. et al. Supramolecular fibrillation of peptide amphiphiles induces environmental responses in aqueous droplets. Nat Commun 12, 6421 (2021). https://doi.org/10.1038/s41467-021-26681-2
DS Minerva
RD 24 abr 2026