RT Journal Article
T1 Structural Screening of Short Peptide Amphiphiles with Autocatalytic Self-Replication
A1 Turcan, Ion
A1 Insua López, Ignacio
AB There is great interest in developing small synthetic molecules that imitate some of the functions and behaviour of living beings. Here, we describe the structural screening of peptide amphiphiles with autocatalytic self-replication, which mimics the perpetuation mechanisms of living matter. Our design uses two reactive precursors to generate self-assembling peptide amphiphiles, which form micelles that catalyse their own synthesis. A collection of precursors with varying sizes was screened combinatorially, revealing a minimal tripeptide amphiphile required to trigger autocatalytic self-replication. These results contribute to the structural simplification of synthetic supramolecular monomers with life-like behaviour.
PB Wiley
YR 2025
FD 2025-01-09
LK https://hdl.handle.net/10347/46952
UL https://hdl.handle.net/10347/46952
LA eng
NO I. Turcan, I. Insua. Structural Screening of Short Peptide Amphiphiles with Autocatalytic Self-Replication. ChemSystemsChem 2025, e202400094. https://doi.org/10.1002/syst.202400094
NO This work was funded by the Agencia Estatal de Investigación (RYC2021-031367-I) and Xunta de Galicia (ED431F 2023/24, ED431 C 2024/09).
DS Minerva
RD 22 may 2026