RT Dissertation/Thesis
T1 New therapeutic approaches to attenuate cancer-associated cachexia
A1 Calviño Lodeiro, Andrea
K1 cancer-associated cachexia
K1 skeletal muscle
K1 EMRS
AB Cancer-associated cachexia is a multifactorial syndrome that is characterised by the progressive loss of skeletal muscle and fat mass. We established two different cancer cachexia mouse models to evaluate the therapeutic potential of extracellular myogenic regulatory signals (EMRS). EMRS treatment improved the muscle function in both models. Mechanistically, EMRS reduced muscle atrophy by inhibiting the catabolic action of the ubiquitin-proteasome system, while also promoting myogenesis and homeostasis of the neuromuscular junctions. Thus, EMRS constitute a promising new approach for treating cancer-associated cachexia.
YR 2026
FD 2026
LK https://hdl.handle.net/10347/46789
UL https://hdl.handle.net/10347/46789
LA eng
DS Minerva
RD 22 may 2026