RT Journal Article
T1 Potent in vitro α-glucosidase inhibition of secondary metabolites derived from dryopteris cycadina
A1 Amin, Surriya
A1 Ullah, Barkat
A1 Ali, Mumtaz
A1 Rauf, Abdur
A1 Khan, Haroon
A1 Uriarte Villares, Eugenio
A1 Sobarzo Sánchez, Eduardo Marcelo
K1 Dryopteris cycadina
K1 Isolated compounds
K1 α-glucosidase inhibition
K1 Molecular docking
AB α-glucosidase is responsible for the hydrolysis of complex carbohydrates into simpleabsorbable glucose and causes postprandial hyperglycemia. α-glucosidase inhibition is thus the idealtarget to prevent postprandial hyperglycemia. The present study was therefore designed to analyzethe effects of various compounds isolated from Dryopteris cycadina against α-glucosidase includingβ-Sitosterol 1, β-Sitosterol3-O-β-D-glucopyranoside 2, 3, 5, 7-trihydroxy-2-(p-tolyl) chorman-4-one 3,Quercetin-3-0-β-D-glucopyranoside (3/→0-3///)- β-D- Quercetin -3-0- β –D-galactopyranoside 4 and5, 7, 4/-Trihydroxyflavon-3-glucopyranoid 5. The in vitro spectrophotometric method was used forthe analysis of test compounds against possible inhibition. Similarly, molecular docking studies wereperformed using the MOE software. These compounds showed concentration-dependent inhibitionon α-glucosidase, and compounds 1 (IC50: 143 ± 0.47 µM), 3 (IC50:133 ± 6.90 µM) and 5 (IC50: 146 ±1.93 µM) were more potent than the standard drug, acarbose (IC50: 290 ± 0.54 µM). Computationalstudies of these compounds strongly supported the in vitro studies and showed strong bindingreceptor sensitivity. In short, the secondary metabolites isolated from D. cycadina demonstratedpotent α-glucosidase inhibition that were supported by molecular docking with a high docking score
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/22471
UL http://hdl.handle.net/10347/22471
LA eng
NO Amin, S.; Ullah, B.; Ali, M.; Rauf, A.; Khan, H.; Uriarte, E.; Sobarzo-Sánchez, E. (2019). Potent in vitro α-glucosidase inhibition of secondary metabolites derived from dryopteris cycadina. Molecules 24(3), 427; doi: 10.3390/molecules24030427
DS Minerva
RD 24 abr 2026