RT Journal Article
T1 Novel microwave-assisted synthesis of the immunomodulator organotellurium compound ammonium trichloro( dioxoethylene- O, O') tellurate ( AS101)
A1 Vázquez Tato, María del Pilar
A1 Mena Menéndez, Alberto
A1 Feás Sánchez, Xesús
A1 Seijas Vázquez, Julio Antonio
K1 Tellurium
K1 AS101
K1 Ammonium trichloro[1,2-ethanediolato-O,O']-tellurate
K1 Microwave irradiation
K1 Antitumoral
AB Ammonium trichloro[1,2-ethanediolato-O,O']-tellurate (AS101) is the mostimportant synthetic Te compound from the standpoint of its biological activity. It is apotent immunomodulator with a variety of potential therapeutic applications andantitumoral action in several preclinical and clinical studies. An experimental design hasbeen used to develop and optimize a novel microwave-assisted synthesis (MAOS) of theAS101. In comparison to the results observed in the literature, refluxing Te(IV) chlorideand ethylene glycol in acetonitrile (Method A), or by refluxing Te(IV) chloride andammonium chloride in ethylene glycol (Method B), it was found that the developedmethods in the present work are an effective alternative, because although performanceslightly decreases compared to conventional procedures (75% vs. 79% by Method A, and45% vs. 51% by Method B), reaction times decreased from 4 h to 30 min and from 4 h to10 min, by Methods A and B respectively. MAOS is proving to be of value in the rapidsynthesis of compounds with new and improved biological activities, specially based onthe benefit of its shorter reaction times
PB MDPI
YR 2014
FD 2014
LK http://hdl.handle.net/10347/22426
UL http://hdl.handle.net/10347/22426
LA eng
NO Vázquez Tato, M.P., Mena Menéndez, A., Feás Sánchez, X. y Seijas Vázquez, J.A. (2014). Novel microwave- assisted synthesis of the immunomodulator organotellurium compound ammonium trichloro( dioxoethylene- O, O') tellurate ( AS101). Int.J.Mol.Sci., vol. 15, 3287-3298
NO We acknowledge XUNTA DE GALICIA for financial support: Grants INCITE09 262346PR andPGIDIT06RAG26103PR. X.F. would also like to thank the Xunta de Galicia (Isidro Parga PondalProgram for young researchers, Grant No. IPP-020)
DS Minerva
RD 24 abr 2026