RT Journal Article
T1 Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide
A1 Gómez González, Jacobo
A1 Martínez Castro, Laura
A1 Tolosa Barrilero, Juan
A1 Alcalde Ordóñez, Ana
A1 Learte Aymamí, Soraya
A1 Mascareñas Cid, José Luis
A1 García Martínez, Joaquín C.
A1 Martínez Costas, José Manuel
A1 Maréchal, Jean-Didier
A1 Vázquez Sentís, Marco Eugenio
AB Non-canonical DNA structures, particularly 3-way junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core
PB Royal Society of Chemistry
SN 1364-548X
YR 2022
FD 2022
LK http://hdl.handle.net/10347/28981
UL http://hdl.handle.net/10347/28981
LA eng
NO Gomez-Gonzalez, J.; Martinez-Castro, L.; Tolosa-Barrilero, J.; Alcalde-Ordoñez, A.; LearteAymamí, S.; Mascareñas, J. L.; García-Martínez, J. C.; Martínez-Costas, J.; Maréchal, J.-D.; Vázquez López, M.; Vázquez, M. E. (2022), Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide. Chem. Commun., 58: 7769-7772. doi: 10.1039/D2CC02874C
DS Minerva
RD 26 abr 2026