RT Journal Article
T1 Recently developed synthetic compounds with anti-infective activity
A1 González Bello, Concepción
K1 Antibiotics
K1 Bacterium
K1 Superbugs
AB The ability of antibiotics to cure bacterial infections is at a serious risk due to the emergence and worldwide spread of superbugs. A lack of innovation and investment for almost 50 years has led to significant efforts currently being devoted to find alternative and innovative therapies to face this challenge. This short review highlights some of the recent efforts to develop synthetic small molecules with anti-infective activity. This article is focused on those compounds that, when co-administered with an antibiotic, enhance the antimicrobial action of the drug, as well as compounds that target unexplored objectives for bacterial survival. Selected examples are provided.
PB Elsevier
SN 1471-4892
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21302
UL http://hdl.handle.net/10347/21302
LA eng
NO González-Bello, C. (2019). Recently developed synthetic compounds with anti-infective activity. Current Opinion In Pharmacology, 48, 17-23. doi: 10.1016/j.coph.2019.03.004
NO Financial support from the Spanish Ministry of Economy andCompetiveness (SAF2016-75638-R), the Xunta de Galicia [Centro Singularde Investigación de Galicia accreditation 2016–2019 (ED431G/09) andED431B 2018/04] and the European Union (European RegionalDevelopment Fund – ERDF is gratefully acknowledged
DS Minerva
RD 27 abr 2026