RT Journal Article
T1 In vivo degeneration and the fate of inorganic nanoparticles
A1 Feliu, Neus
A1 Docter, Dominic
A1 Heine, Markus
A1 Pino González de la Higuera, Pablo Alfonso del
A1 Ashraf, Sumaira
A1 Kolosnjaj-Tabi, Jelena
A1 Macchiarini, Paolo
A1 Nielsen, Peter
A1 Alloyeau, Damien
A1 Gazeau, Florence
A1 Stauber, Roland H.
A1 Parak, Wolfgang J.
AB What happens to inorganic nanoparticles (NPs), such as plasmonic gold or silver, superparamagnetic iron oxide, or fluorescent quantum dot NPs after they have been administrated to a living being? This review discusses the integrity, biodistribution, and fate of NPs after in vivo administration. The hybrid nature of the NPs is described, conceptually divided into the inorganic core, the engineered surface coating comprising of the ligand shell and optionally also bio-conjugates, and the corona of adsorbed biological molecules. Empirical evidence shows that all of these three compounds may degrade individually in vivo and can drastically modify the life cycle and biodistribution of the whole heterostructure. Thus, the NPs may be decomposed into different parts, whose biodistribution and fate would need to be analyzed individually. Multiple labeling and quantification strategies for such a purpose will be discussed. All reviewed data indicate that NPs in vivo should no longer be considered as homogeneous entities, but should be seen as inorganic/organic/biological nanohybrids with complex and intricately linked distribution and degradation pathways
PB Royal Society of Chemistry
SN 0306-0012
YR 2016
FD 2016
LK http://hdl.handle.net/10347/19753
UL http://hdl.handle.net/10347/19753
LA eng
NO Chem. Soc. Rev., 2016,45, 2440-2457
NO This work was partly funded by the European Commission (grant FutureNanoNeeds to WJP), the MINECO (MAT2013-48169-R, NanoFATE, to WJP and PdP), BMBF-MRCyte/NanoBEL, Zeiss-ChemBioMed, Stiftung Rheinland-Pfalz (NanoScreen), Peter und Traudl Engelhorn foundation, BIOMATICS (grants to RS, DD), DFG SPP1313 (grants to RS, PN, WJP), the CNRS (Centre National de la Recherche Scientifique, Defi Nano program), the ANR (Agence Nationale de la Recherche) and CGI (Commissariat à l'Investissement d'Avenir) through the LabEx SEAM (Science and Engineering for Advanced Materials and devices; ANR 11 LABX 086, ANR 11 IDEX 05 02) (grants to DA and FG). SA acknowledges the Alexander von Humboldt Foundation for a PostDoc fellowship and NF the Lars Hierta Memorial Foundation
DS Minerva
RD 22 abr 2026