RT Journal Article
T1 A very-low-calorie ketogenic diet normalises obesity-related enhanced levels of erythropoietin compared with a low-calorie diet or bariatric surgery
A1 Fernández-Pombo, Antía
A1 Mariño Lorenzo, Paula
A1 Couselo Carreira, Marcos
A1 Gomez Arbelaez, Diego
A1 Castro País, Ana Isabel
A1 Primo Martín, David
A1 Rodríguez López, Julio
A1 Sajoux, Ignacio
A1 Baltar, Javier
A1 Luis Román, Daniel Antonio de
A1 Bellido Guerrero, Diego
A1 Crujeiras Martínez, Ana Belén
A1 Casanueva Freijo, Felipe
K1 Adiposity
K1 Erythropoietin
K1 Nutritional ketosis
K1 Energy restriction
K1 Ketone bodies
AB PurposeNutritional ketosis synergistically with body-weight loss induced by a very-low-calorie ketogenic diet (VLCKD) has proven to be effective in improving obesity-related pathophysiology. Recently, growing attention has been focused on the relation between erythropoietin (EPO) and obesity. Thus, this study aims to investigate whether nutritional ketosis and weight loss induced by a VLCKD modify the circulating levels of EPO in patients with obesity in comparison with the effect of low-calorie diet (LCD) or bariatric surgery (BS).MethodsEPO levels, iron status and body composition parameters were evaluated in 72 patients with overweight or obesity and 27 normal-weight subjects at baseline and after the three different weight-reduction therapies (VLCKD, LCD and BS) in 69 patients with excess body weight. β-hydroxybutyrate levels were also measured in the VLCKD group. The follow-up was established at 2–3 months and 4–6 months.ResultsIt was found that EPO levels were higher in morbid obesity and correlated with higher basal weight, fat mass (FM) and fat-free mass (FFM) in the overall sample. High baseline EPO levels were also correlated with higher impact on the course of weight loss and changes in FM and FFM induced by the three weight-loss interventions. Furthermore, the VLCKD induced a decrease in EPO levels coinciding with maximum ketosis, which was maintained over time, while statistically significant changes were not observed after LCD and BS.ConclusionThe obesity-related increased EPO levels are restored after VLCKD intervention at the time of maximum ketosis, suggesting a potential role of the nutritional ketosis induced by the VLCKD. Baseline EPO levels could be a biomarker of response to a weight-loss therapy
PB Springer
YR 2024
FD 2024-05-02
LK http://hdl.handle.net/10347/34898
UL http://hdl.handle.net/10347/34898
LA eng
NO J Endocrinol Invest (2024)
NO This work was supported by PronoKal Group® and grants from the Instituto de Salud Carlos III (ISCIII)-Subdireccion General de Evaluacion y Fomento de la Investigacion; European Regional Development Fund (ERDF) (PI20/00650, PI20/00628 and CP17/00088 research projects and CIBERobn) and by Xunta de Galicia-GAIN (IN607B2020/09). Ana B Crujeiras is funded by a Miguel Servet research contract (CP17/00088 and CPII22/00008) and Antia Fernandez-Pombo was funded by a Rio Hortega research contract (CM20/00155) from the ISCIII, co-financed by ERDF, received  funding from the Fundación Alfonso Martín Escudero and is currently funded by a Juan Rodes research contract (JR23/00042) from the ISCIII, co-financed by ERDF. Paula M Lorenzo was funded by a predoctoral grant from Xunta de Galicia (IN606-2020/013)
DS Minerva
RD 28 abr 2026