RT Journal Article
T1 A ‘click chemistry’ approach to the straightforward synthesis of new 4-aryl-1,2,3-triazolocarbanucleosides
A1 Pérez Castro, Isabel
A1 Caamaño Santos, María Olga
A1 Fernández González, Franco
A1 García, Marcos D.
A1 López Santamaría, María del Carmen
A1 Clercq, Erik de
K1 Click chemistry
K1 Triazoles
K1 Carbanucleosides
K1 Antiviral
K1 Ribavirin
AB The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3-triazolyl carbanucleosides of type (±)-10/(±)-11 related to the broad spectrum antiviral agentribavirin 1 are described. These compounds were produced using a “click chemistry” strategystarting from readily available protected alcohol 13b. The synthetic approach made use of olefinbased organic reactions for the stereoselective construction of the appropriately functionalizedcyclopentane ring moiety followed by copper (I) catalyzed Huisgen 1,3-dipolar cycloaddition ofazides and alkynes for the regioselective construction of the heterocyclic triazole moiety
PB Arkat USA Inc
SN 1551-7012
YR 2010
FD 2010
LK http://hdl.handle.net/10347/23463
UL http://hdl.handle.net/10347/23463
LA eng
NO Pérez-Castro, Isabel, Caamaño, Olga, Fernández, Franco, García, Marcos D., López, Carmen, Clercq, Eirik D. A ‘click chemistry’ approach to the straightforward synthesis of new 4-aryl-1,2,3-triazolocarbanucleosides . ARKIVOC 2010 p. 152-168
NO The authors thank the Xunta de Galicia for financial support of this work under ProjectPGIDT02BTF20305PR. M.D.G. thanks the Xunta de Galicia for financial support under“Programa Isidro Parga Pondal”
DS Minerva
RD 28 abr 2026