RT Journal Article
T1 Self-assembling molecular capsules based on alpha, gamma-Cyclic peptides
A1 Ozores, Lionel Haxel
A1 Amorín López, Manuel
A1 Granja Guillán, Juan Ramón
K1 Self-assembling
K1 Cyclic peptide
K1 Supramolecular chemistry
AB A new capsule based on a β-sheet self-assembling cyclic peptide with the ability to recognize and release several guests is described. The host structure is composed of two self-complementary α,γ-cyclic peptides bearing a Zn porphyrin cap that is used for the selective recognition of the guest. The two components are linked through two dynamic covalent bonds. The combination of binding forces, including hydrogen bonding, metal coordination, and dynamic hydrazone bonds, allows the reversible recognition of long bipyridine guests. The affinity for these ligands showed a strong dependence on the guest length. Delivery of the encapsulated ligand can be achieved by hydrolysis of hydrazones to disrupt the sandwich complex structure
PB American Chemical Society
SN 0002-7863
YR 2016
FD 2016-12-20
LK http://hdl.handle.net/10347/17002
UL http://hdl.handle.net/10347/17002
LA eng
NO Ozores, L.H., Amorín, M., & Granja, J. (2017). Self-Assembling Molecular Capsules Based on α,γ-Cyclic Peptides. Journal of the American Chemical Society, 2017, 139 (2), pp 776–784. http://dx.doi.org/10.1021/jacs.6b10456
NO H. L. O. thanks Mineco for his FPU contract and the Diputación de A Coruña for his research fellowship. We also thank the ORFEO-CINCA network
DS Minerva
RD 29 abr 2026