RT Journal Article
T1 Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media
A1 Destito, Paolo
A1 Sousa Castillo, Ana
A1 Rodríguez Couceiro, José
A1 López García, Fernando
A1 Correa Duarte, Miguel Ángel
A1 Mascareñas Cid, José Luis
AB We describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles and their use as Pd-nanoreactors in aqueous media. These palladium-equipped capsules can be used to promote the uncaging of propargyl-protected phenols, as well as Suzuki–Miyaura cross-coupling, in water and at physiologically compatible temperatures. Importantly, the depropargylation reaction can be accomplished in a bioorthogonal manner in the presence of relatively high concentrations of biomolecular components and even in the presence of mammalian cells
PB Royal Society of Chemistry
SN 2041-6539
YR 2019
FD 2019
LK http://hdl.handle.net/10347/18462
UL http://hdl.handle.net/10347/18462
LA eng
NO Destito, P., Sousa-Castillo, A., Couceiro, J., López, F., Correa-Duarte, M., & Mascareñas, J. (2019). Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media. Chemical Science, 10(9), 2598-2603. doi: 10.1039/c8sc04390f
NO This work has received financial support from Spanish grants(SAF2016-76689-R, CTQ2017-84767-P, CTM2014-58481-R,CTM2017-84050-R and Orfeo-Cinqa network CTQ2016-81797-REDC), the Consellería de Cultura, Educación e OrdenaciónUniversitaria (2015-CP082, ED431C/2017119 and CentroSingular de Investigación de Galicia accreditation 2016–2019,ED431G/09), the European Union (European Regional Development Fund-ERDF corresponding to the multiannual financialframework 2014–2020), and the European Research Council(Advanced Grant No. 340055)
DS Minerva
RD 28 abr 2026