RT Journal Article
T1 Synthetic peptide scaffolds as ion channels and molecular carriers
A1 Pérez-Pérez, Manuel
A1 Fuertes, Alberto
A1 Montenegro García, Javier
K1 Canales iónicos
K1 Péptidos
K1 Andamiajes moleculares
AB Transmembrane ion exchange controls biological functions and is essential for life. Over the years, a great variety of nature-inspired artificial ion channels and carriers have been synthesized to control and promote ion exchange across biological membranes. In this context, peptides emerged as ideal scaffolds for synthetic ion channels due to their biocompatibility, accessibility and chemical versatility. Peptides have already shown their potential for the construction of a range of synthetic ion transporters either alone or in combination with other molecular scaffolds. Among the great diversity of peptide-based ion transporters, we can find key examples of single-molecule and supramolecular transmembrane ion channels and ionophores. Peptide scaffolds have also found great potential for the transmembrane delivery of biomolecular cargos such as nucleic acids and proteins. This review covers some of the most relevant advances in the peptide-based ion transport field from the last few years.
PB Elsevier
SN 1367-5931
YR 2026
FD 2026
LK https://hdl.handle.net/10347/40075
UL https://hdl.handle.net/10347/40075
LA eng
NO Pérez-Pérez, M., Fuertes, A., Montenegro, J. (2025). Synthetic peptide scaffolds as ion channels and molecular carriers. "Current Opinion In Chemical Biology", vol. 84, 102563
NO The authors thank the Spanish Agencia Estatal de Investigación (AEI) [PID2020-117143RB-I00, PID2023-152181OB-I00], Xunta de Galicia (ED431C 2024/03, ED481A-2024-049), the ERDF. J.M. thanks GAIN for an Oportunius Contract and M.P.-P. received a Xunta de Galicia predoctoral fellowhip (ED481A- 2023/145)
DS Minerva
RD 24 abr 2026