RT Journal Article
T1 Effect on nail structure and transungual permeability of the ethanol and poloxamer ratio from cyclodextrin-soluble polypseudorotaxanes based nail lacquer
A1 Cutrín Gómez, Elena
A1 Anguiano Igea, Soledad
A1 Delgado Charro, M Begoña
A1 Gómez Amoza, José Luis
A1 Otero Espinar, Francisco Javier
K1 Transungual drug delivery
K1 Nail
K1 Medicated nail lacquers
K1 Onychomycosis
K1 Nail psoriasis ungueal
K1 Polypseudorotaxanes
K1 Methyl-β-cyclodextrin
K1 Poloxamers;
K1 Ciclopirox olamine
K1 Clobetasol propionate
AB Aqueous-based nail lacquers have shown potential in promoting the diffusion of drugs into the nail. In our laboratory, we have recently developed a transungual delivery system based on an aqueous dispersion of cyclodextrin-poloxamer soluble polypseudorotaxanes, supramolecular host−guest assemblies that improves the drug permeation into the nail. However, the high-water content and the rheological and adhesive properties of this lacquer negatively affect properties that play a fundamental role in the patients’ acceptance such as stickiness, nail film formation or drying rate, properties. In this work, we have optimized the composition of these lacquers to improve these properties whilst maintaining good drug permeation profiles. Incorporating ethanol into the vehicle and reducing the proportion of Poloxamer 407 (PL), provided a good strategy. The use of hydro-ethanolic mixtures (>50% ethanol) and the reduction of the poloxamer concentration significantly improved the lacquer drying speed by reducing the stickiness and promoting film formation on the nail surface. Additionally, in a surprising way, the use of hydro-ethanolic vehicles further enhanced the permeation of ciclopirox olamine and clobetasol propionate, used for the treatment of onychomycosis and nail psoriasis respectively, into the nail and hooves
PB MDPI
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22548
UL http://hdl.handle.net/10347/22548
LA eng
NO Cutrín-Gómez, E.; Anguiano-Igea, S.; Delgado-Charro, M.B.; Gómez-Amoza, J.L.; Otero-Espinar, F.J. Effect on Nail Structure and Transungual Permeability of the Ethanol and Poloxamer Ratio from Cyclodextrin-Soluble Polypseudorotaxanes Based Nail Lacquer. Pharmaceutics 2018, 10, 156
NO ECG acknowledges Xunta de Galicia for their Predoctoral Grant. Authors acknowledges Roquette Laisa by the generous gift of the methyl- -cyclodextrin (Kleptose Crismeb)
DS Minerva
RD 26 abr 2026