RT Journal Article
T1 Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study
A1 Suárez Gestal, María de los Ángeles
A1 Pérez Pampín, Eva
A1 Calaza Cabanas, Manuel
A1 Gómez-Reino Carnota, Juan Jesús
A1 González Martínez-Pedrayo, Antonio
K1 Rheumatoid Arthritis
K1 Infliximab
K1 Etanercept
K1 Adalimumab
K1 Genome
K1 Wide
K1 Association Study
AB IntroductionWe aimed to replicate the strong associations that a recent genome wide association study (GWAS) has found between 16 single nucleotide polymorphisms (SNPs) and response to anti-tumour necrosis factor (TNF) treatment in 89 patients with rheumatoid arthritis (RA). This study is very important because, according to published simulations, associations as strong as the reported ones will mean that these SNPs could be used as predictors of response at the individual level.MethodsDisease activity score (DAS28) was evaluated in 151 anti-TNF treated patients with RA of Spanish ancestry at baseline and every 3 months thereafter. Genotypes of the 16 putative predictor SNPs were obtained by single-base extension. Association between the relative change in DAS28 and SNP genotypes was tested by linear regression. In addition, logistic regression was applied to compare genotypes in non-responders (n = 34) versus good-responders (n = 61) following the EULAR response criteria.ResultsNone of the analyses showed any significant association between the 16 SNPs and response to anti-TNF treatments at 3 or 6 months. Results were also negative when only patients treated with infliximab (66.9% of the total) were separately analyzed. These negative results were obtained in spite of a very good statistical power to replicate the reported strong associations.ConclusionsWe still do not have any sound evidence of genetic variants associated with RA response to anti-TNF treatments. In addition, the possibility we had envisaged of using the results of a recent GWAS for prediction in individual patients should be dismissed
PB BMC
SN 1478-6354
YR 2010
FD 2010
LK http://hdl.handle.net/10347/23075
UL http://hdl.handle.net/10347/23075
LA eng
NO Suarez-Gestal, M., Perez-Pampin, E., Calaza, M. et al. Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study. Arthritis Res Ther 12, R72 (2010). https://doi.org/10.1186/ar2990
NO MS-G is the recipient of an FPU predoctoral bursary of the Spanish Ministry of Education. MC is the recipient of an 'Isabel Barreto' bursary of the government of Galicia. This project was supported by an unrestricted grant from Roche Spain and by grants PI080744 and PI09/90744 from the Instituto de Salud Carlos III (Spain) with participation of funds from FEDER (European Union)
DS Minerva
RD 26 abr 2026