The impact of transposable elements on the structure and function of the cancer genome
| dc.contributor.advisor | Castro Tubío, José Manuel | |
| dc.contributor.affiliation | Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS) | |
| dc.contributor.author | Rodríguez Martín, Bernardo | |
| dc.date.accessioned | 2022-06-29T08:00:05Z | |
| dc.date.available | 2022-06-29T08:00:05Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | This PhD dissertation provides further insights on the impact of retrotransposon mobilisation in the cancer genome. Through the analysis of a large cohort of 2,954 cancer whole genomes compiled by the Pan-Cancer Analysis of Whole Genomes Consortium, we have investigated the patterns of somatic activity for mobile elements across 38 different tumour types, uncovered novel mechanisms of mutation mediated by LINE-1 elements and characterised more than 100 full-length LINE-1 loci active in cancer. | gl |
| dc.description.programa | Universidade de Santiago de Compostela. Programa de Doutoramento en Medicina Molecular | |
| dc.identifier.uri | http://hdl.handle.net/10347/28860 | |
| dc.language.iso | eng | gl |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | |
| dc.rights.accessRights | open access | gl |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Retrotransposones | gl |
| dc.subject | Cancer | gl |
| dc.subject | Biología Computacional | gl |
| dc.subject.classification | Materias::Investigación::24 Ciencias de la vida::2410 Biología humana::241007 Genética humana | gl |
| dc.title | The impact of transposable elements on the structure and function of the cancer genome | gl |
| dc.type | doctoral thesis | gl |
| dspace.entity.type | Publication | |
| relation.isAdvisorOfPublication | 23630713-5e80-4fc3-b18a-a6bd2b460d5f | |
| relation.isAdvisorOfPublication.latestForDiscovery | 23630713-5e80-4fc3-b18a-a6bd2b460d5f |
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