Evaluation of differential effects of metformin treatment in obese children according to pubertal stage and genetic variations: study protocol for a randomized controlled trial

Simple item page
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatríagl
dc.contributor.authorPastor Villaescusa, Belén
dc.contributor.authorCaballero Villarraso, Javier
dc.contributor.authorCañete, M. Dolores
dc.contributor.authorHoyos, Raúl
dc.contributor.authorMaldonado, José
dc.contributor.authorBueno, Gloria
dc.contributor.authorLeis Trabazo, María Rosaura
dc.contributor.authorCañete, Ramón
dc.contributor.authorAguilera, Concepción M.
dc.date.accessioned2017-10-20T22:27:57Z
dc.date.available2017-10-20T22:27:57Z
dc.date.issued2016-07-18
dc.description.abstractOverweight and obesity are considered to be serious public health problems. In pediatric populations, insulin resistance, dyslipidemia, and hypertension associated with obesity occur with increased frequencies. Metformin is an oral anti-hyperglycemic agent that has been demonstrated to be efficacious in the treatment of diabetic and non-diabetic obese adults. A considerable amount of pharmacogenetic research has demonstrated that genetic variation is one of the major factors affecting metformin response. Additionally, potential microbiota-mediated mechanisms of metformin effect have been recently described. However, scant work has been conducted in children, with no attention being paid to the potential effects of pubertal development. Thus, the main objective of the present study is to evaluate the effect of metformin treatment together with lifestyle recommendations in a randomized control trial (RCT) of obese children according to pubertal stage, genetic variants and signature of gut microbiotagl
dc.description.peerreviewedSIgl
dc.description.sponsorshipWe would like to acknowledge the Spanish Ministry of Health, Social and Equality, General Department for Pharmacy and Health Products for financing this study; RETICS funded by the PN I + D + I 2008–2011 (Spain), ISCIII- Sub-Directorate General for Research Assessment and Promotion and The European Regional Development Fund (ERDF), Ref. Rd12/0026. Furthermore, the members of the project group who participate in the data and sample collection and the development of the FFQ (Miriam Latorre, PhD student, Pediatric Department, Lozano Blesa University Hospital, University of Zaragoza. Zaragoza, Spain; Rocío Vazquez-Cobela, PhD student, Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department, Clinic University Hospital of Santiago, University of Santiago de Compostela. Santiago de Compostela, Spain). This paper will be part of María Belén Pastor Villaescusa’s doctorate, which is being performed within the “Nutrition and Food Sciences Program” at the University of Granadagl
dc.identifier.citationPastor-Villaescusa, Belén, Javier Caballero-Villarraso, M. Dolores Cañete, Raúl Hoyos, José Maldonado, Gloria Bueno, Rosaura Leis, Ángel Gil, Ramón Cañete, and Concepción M. Aguilera. 2016. "Evaluation Of Differential Effects Of Metformin Treatment In Obese Children According To Pubertal Stage And Genetic Variations: Study Protocol For A Randomized Controlled Trial". Trials 17 (1). doi:10.1186/s13063-016-1403-4gl
dc.identifier.doi10.1186/s13063-016-1403-4
dc.identifier.issn1745-6215
dc.identifier.urihttp://hdl.handle.net/10347/15918
dc.language.isoenggl
dc.publisherBioMed Centralgl
dc.relation.publisherversionhttps://doi.org/10.1186/s13063-016-1403-4gl
dc.rights© 2016 Pastor-Villaescusa et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise statedgl
dc.rights.accessRightsopen accessgl
dc.subjectMetformingl
dc.subjectChildrengl
dc.subjectObesitygl
dc.subjectPubertygl
dc.subjectLifestyle interventiongl
dc.subjectMicrobiotagl
dc.subjectPolymorphismsgl
dc.titleEvaluation of differential effects of metformin treatment in obese children according to pubertal stage and genetic variations: study protocol for a randomized controlled trialgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublication1e3d57c2-ad35-4203-8ea0-f72f75021208
relation.isAuthorOfPublication.latestForDiscovery1e3d57c2-ad35-4203-8ea0-f72f75021208

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
2016_trials_pastor_evaluation_differential.pdf
Size:
606.12 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia e Pediatría