Gold(I)-catalyzed enantioselective addition and cycloaddition reactions

Abstract

This Doctoral Thesis has been focused on the development of new gold(I)-catalyzed enantioselective addition and cycloaddition reactions.

In particular, in the first chapter, dedicated to the development of enantioselective addition reactions, we describe the discovery of the first intermolecular reaction involving the synergistic combination of an enamine-mediated organocatalysis and a gold (I) catalyst, providing the products with moderate to good levels of enantioselectivity.

In the second chapter, we describe the successful development of an enantioselective gold(I)-catalyzed (2+2+2) cascade cycloaddition between N-allenamides and alkenyl-oximes, constituting one of the very few catalytic and enantioselective methods that allowed to build aza-bridged bicyclic systems from readily available acyclic starting materials.