Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Físicagl
dc.contributor.authorPenas Tallón, Cristina
dc.contributor.authorSánchez López, Mateo Isidro
dc.contributor.authorGuerra Varela, Jorge
dc.contributor.authorSánchez Piñón, Laura
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2019-03-27T15:01:44Z
dc.date.available2019-03-27T15:01:44Z
dc.date.issued2016
dc.descriptionThis is the peer reviewed version of the following article: C. Penas, M. I. Sánchez, J. Guerra-Varela, L. Sanchez, M. E. Vázquez, J. L. Mascareñas, ChemBioChem 2016, 17, 37-41, which has been published in final form at https://doi.org/10.1002/cbic.201500455. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versionsgl
dc.description.abstractWe synthesized octa‐arginine conjugates of DNA‐binding agents (bisbenzamidine, acridine and Thiazole Orange) and demonstrated that their DNA binding and cell internalization can be inhibited by appending a (negatively charged) oligoglutamic tail through a photolabile linker. UV irradiation released the parent conjugates, thus restoring cell internalization and biological activity. Assays with zebrafish embryos demonstrates the potential of this prodrug strategy for controlling in vivo cytotoxicitygl
dc.description.peerreviewedSIgl
dc.description.sponsorshipWe are thankful for the support given by the Spanish grants SAF2013–41943‐R, CTQ2012–31341 and CTQ2013–49317‐EXP, the Xunta de Galicia GRC2013–041, the ERDF and the European Research Council (Advanced Grant 340055). C.P. and M.I.S. thank the Spanish MCINN for their PhD fellowshipsgl
dc.identifier.citationC. Penas, M. I. Sánchez, J. Guerra-Varela, L. Sanchez, M. E. Vázquez, J. L. Mascareñas (2016). Light‐Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid‐Binding Agents: Studies in Vitro and in Zebrafish Embryos. ChemBioChem, 17, 37-41. DOI: 10.1002/cbic.201500455gl
dc.identifier.doi10.1002/cbic.201500455
dc.identifier.essn1439-7633
dc.identifier.urihttp://hdl.handle.net/10347/18485
dc.language.isoenggl
dc.publisherWileygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.publisherversionhttps://doi.org/10.1002/cbic.201500455gl
dc.rights© 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versionsgl
dc.rights.accessRightsopen accessgl
dc.subjectDNA recognitiongl
dc.subjectCaged compoundsgl
dc.subjectFluorescent probesgl
dc.subjectPeptidesgl
dc.subjectSupramolecular chemistrygl
dc.titleLight-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryosgl
dc.typejournal articlegl
dc.type.hasVersionAMgl
dspace.entity.typePublication
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relation.isAuthorOfPublication34f1e1e8-411b-4b42-a25c-253481d3abef
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication.latestForDiscovery017b2725-d3de-40d7-8859-18c50f038d1d

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