Peptide–DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

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2015_OrgBiomolChem_Pazos_peptide.pdf (801.22 KB)
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URI: http://hdl.handle.net/10347/18491
ISSN: 1477-0520
E-ISSN: 1477-0539
DOI: 10.1039/C5OB00318K

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2015

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Royal Society of Chemistry
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We describe a ds-oligonucleotide–peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways

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Pazos, E., Portela, C., Penas, C., Vázquez, M., & Mascareñas, J. (2015). Peptide–DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun. Org. Biomol. Chem., 13, 5385-5390. doi: 10.1039/c5ob00318k

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We thank the financial support provided by the Spanish grants SAF2010-20822-C02, SAF2013-41943-R and CTQ2012-31341, the Xunta de Galicia GRC2013-041 and the ERDF. E.P. thanks the Xunta de Galicia for her postdoctoral contract; C.P. and C.P. thank the Spanish Government for their Ph.D. fellowship

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© The Royal Society of Chemistry 2015

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Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)
Química Orgánica