Complexation of 3α,7α,12α-trihydroxy-5β-cholan-24-amine by β- and γ-cyclodextrins

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Físicagl
dc.contributor.authorAntelo Queijo, Álvaro
dc.contributor.authorÁlvarez Alcalde, María de las Mercedes
dc.contributor.authorJover Ramos, Aida
dc.contributor.authorMeijide del Río, Francisco Ángel
dc.contributor.authorGalantini, Luciano
dc.contributor.authorVázquez Tato, José
dc.date.accessioned2021-08-19T08:31:43Z
dc.date.available2021-08-19T08:31:43Z
dc.date.issued2009
dc.descriptionThe 13th International Electronic Conference on Synthetic Organic Chemistry session Polymer and Supramolecular Chemistrygl
dc.description.abstractThe binding constants, standard molar enthalpy, Gibbs free energy, and entropy changes were determined for the formation of inclusion complexes between 3α,7α,12α- trihydroxy-5β-cholan-24-amine, C24NH2, and β-cyclodextrin and γ-cyclodextrin. The stoichiometry of both complexes is 1:1 in agreement with previously reported results for other trihydroxy bile salts. The equilibrium constant values for the formation of the inclusion complex are similar as well. The structure of the C24NH2/γ-cyclodextrin complex was studied by ROESY experiments. These results suggest that B, C and Drings of the steroid skeleton, as well as the side chain, interact with the cyclodextrin cavity, while the A ring of the steroid nucleus remains outside the cavitygl
dc.description.sponsorshipThe authors from USC thank the Ministerio de Ciencia y Tecnología (Project MAT2004-04606) and Xunta de Galicia (PGIDIT05PXIC26201PN) for financial supportgl
dc.identifier.citationVázquez Tato, J.; Galantini, L.; Meijide, F.; Jover, A.; Alvarez Alcalde, M.; Antelo, A. Complexation of 3α,7α,12α-trihydroxy-5β-cholan-24-amine by β- and γ-cyclodextrins, in Proceedings of the 13th International Electronic Conference on Synthetic Organic Chemistry, 1–30 November 2009, MDPI: Basel, Switzerland, doi:10.3390/ecsoc-13-00259gl
dc.identifier.doi10.3390/ecsoc-13-00259
dc.identifier.isbn3-906980-23-5
dc.identifier.urihttp://hdl.handle.net/10347/26863
dc.language.isoenggl
dc.publisherMDPIgl
dc.relation.ispartofseriesElectronic Conference on Synthetic Organic Chemistry;13
dc.relation.projectIDinfo:eu-repo/grantAgreement/MEC/Plan Nacional de I+D+i 2004-2007/MAT2004-04606/ESgl
dc.relation.publisherversionhttps://doi.org/10.3390/ecsoc-13-00259gl
dc.rights© 2009 The author(s). Published by MDPI, Basel, Switzerland. Open Accessgl
dc.rights.accessRightsopen accessgl
dc.titleComplexation of 3α,7α,12α-trihydroxy-5β-cholan-24-amine by β- and γ-cyclodextrinsgl
dc.typebook partgl
dspace.entity.typePublication
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relation.isAuthorOfPublicationb8762842-f2c1-4e17-9c74-bc63e2c87ef1
relation.isAuthorOfPublication9d4dce74-ef7a-4034-8bba-a512e94133ef
relation.isAuthorOfPublication.latestForDiscovery4fca9fe8-5893-4006-8a8b-31928d178951

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