Oligoalanine helical callipers for cell penetration

Thumbnail Image

Files

2018_chemcomm_pazo_oligoalanine_helical.pdf (472.01 KB)
2018_chemcomm_pazo_oligoalanine_helical_sup_info.pdf (23.36 MB)
Identifiers
URI: http://hdl.handle.net/10347/16956
ISSN: 1359-7345
E-ISSN: 1364-548X
DOI: 10.1039/C8CC02304B

Publication date

2018-05-23

Authors

Advisors

Tutors

Editors

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry
Metrics
Google Scholar
lacobus
Export

Research Projects

Organizational Units

Journal Issue

Abstract

Even for short peptides that are enriched in basic amino acids, the large chemical space that can be spanned by combinations of natural amino acids hinders the rational design of cell penetrating peptides. We here report on short oligoalanine scaffolds for the fine-tuning of peptide helicity in different media and the study of cell penetrating properties. This strategy allowed the extraction of the structure/activity features required for maximal membrane interaction and cellular penetration at minimal toxicity. These results confirmed oligoalanine helical callipers as optimal scaffolds for the rational design and the identification of cell penetrating peptides

Description

This is the accepted manuscript of the following article: Pazo, M., Juanes, M., Lostalé-Seijo, I., & Montenegro, J. (2018). Oligoalanine helical callipers for cell penetration. Chem. Commun., 2018, 54, 6919-6922. doi: 10.1039/c8cc02304b. This article may be used for non-commercial purposes in accordance with RSC Terms and Conditions for self-archiving

Keywords

Bibliographic citation

Pazo, M., Juanes, M., Lostalé-Seijo, I., & Montenegro, J. (2018). Oligoalanine helical callipers for cell penetration. Chemical Communications, 54(50), 6919-6922. doi: 10.1039/c8cc02304b

Relation

Has part

Has version

Is based on

Is part of

Is referenced by

Is version of

Requires

Sponsors

This work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [CTQ2014-59646-R, SAF2017-89890-R], the Xunta de Galicia (ED431G/09, ED431C 2017/25 and 2016-AD031) and the ERDF. M. P. thanks the Xunta de Galicia for a pre-doctoral fellowship (ED481A-2017/142), and M. J. MINECO for a F. P. I. fellowship. J. M. received a Ramón y Cajal (RYC-2013-13784), an ERC Starting Investigator Grant (DYNAP-677786) and a Young Investigator Grant from the Human Frontier Science Research Program (RGY0066/2017)

Rights

© Royal Society of Chemistry 2018. This article may be used for non-commercial purposes in accordance with RSC Terms and Conditions for self-archiving

Collections

Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)
Química Orgánica