The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorRodríguez Villar, Jéssica
dc.contributor.authorMosquera Mosquera, Jesús
dc.contributor.authorRodríguez Couceiro, José
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2019-03-12T07:53:08Z
dc.date.available2019-03-12T07:53:08Z
dc.date.issued2015
dc.description.abstractWe report the development of chimeric DNA binding peptides comprising a DNA binding fragment of natural transcription factors (the basic region of a bZIP protein or a monomeric zinc finger module) and an AT-Hook peptide motif. The resulting peptide conjugates display high DNA affinity and excellent sequence selectivity. Furthermore, the AT-Hook motif also favors the cell internalization of the conjugatesgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipWe are thankful for the support given by the Spanish grants SAF2013-41943 R, CTQ2012-31341, and CTQ2013-49317-EXP; the Xunta de Galicia GRC2013-041, the ERDF and the European Research Council (Advanced Grant 340055). Support of COST Action CM1105 and the Orfeo-Cinqa also is kindly acknowledged. J.R. thanks the Xunta de Galicia for her PhD fellowshipgl
dc.identifier.citationRodríguez, J., Mosquera, J., Couceiro, J., Vázquez, M., & Mascareñas, J. (2015). The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments. Chemical Science, 6(8), 4767-4771. doi: 10.1039/c5sc01415hgl
dc.identifier.doi10.1039/c5sc01415h
dc.identifier.essn2041-6539
dc.identifier.urihttp://hdl.handle.net/10347/18337
dc.language.isoenggl
dc.publisherRoyal Society of Chemistrygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-49317/ES/EXPLORACION DE TERAPIAS ANTITUMORALES ALTERNATIVAS DIRIGIDAS A LAS MITOCONDRIAS
dc.relation.publisherversionhttps://doi.org/10.1039/C5SC01415Hgl
dc.rights© The Royal Society of Chemistry 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedgl
dc.rights.accessRightsopen accessgl
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.titleThe AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragmentsgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublication1b4c7a3c-215b-42bf-9ce2-c533031318dc
relation.isAuthorOfPublication34f1e1e8-411b-4b42-a25c-253481d3abef
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication.latestForDiscovery1b4c7a3c-215b-42bf-9ce2-c533031318dc

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