Gold(I)-catalyzed [2 + 2 + 2] cycloaddition of allenamides, alkenes and aldehydes: a straightforward approach to tetrahydropyrans

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.contributor.authorFaustino, Hélio
dc.contributor.authorVarela Sandá, Iván
dc.contributor.authorMascareñas Cid, José Luis
dc.contributor.authorLópez García, Fernando
dc.date.accessioned2015-04-27T10:58:19Z
dc.date.available2015-04-27T10:58:19Z
dc.date.issued2015-03-02
dc.description.abstractAllenamides participate as two-carbon components in an intermolecular [2 + 2 + 2] cycloaddition with alkenes and aldehydes when treated with catalytic amounts of a phosphite gold complex. The reaction is highly regio- and chemoselective, and works with different types of alkenes, including styrenes, enolethers or enamides, as well as with aromatic and aliphatic aldehydes. Accordingly, different types of 2,6- disubstituted tetrahydropyrans can be stereoselectively assembled in a single step from commercial or very accessible starting materialsgl
dc.description.sponsorshipThis work was supported by the Spanish MINECO (SAF2013-41943-R, SAF2010-20822-C02), the ERDF, the European Research Council (Adv. Grant no. 340055) and the Xunta de Galicia (GRC2013-041). HF acknowledges the Fundação para a Ciência e Tecnologia(Portugal) and POPH/FSE for a PhD grant (SFRH/BD/60214/2009)gl
dc.identifier.citationFaustino, H., Varela, I., Mascareñas Cid, J.L. & López, F. (2015). Gold(I)-catalyzed [2 + 2 + 2] cycloaddition of allenamides, alkenes and aldehydes: a straightforward approach to tetrahydropyrans. "Chemical Science", 6, 2903-2908 [10.1039/C5SC00295H]gl
dc.identifier.doi10.1039/C5SC00295H
dc.identifier.issn2041-6520
dc.identifier.otherE-ISSN 2041-6539
dc.identifier.urihttp://hdl.handle.net/10347/13247
dc.language.isoenggl
dc.publisherRoyal Society of Chemistrygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-41943-R/ES/HERRAMIENTAS SINTETICAS EN QUIMICA BIOLOGICA. NUEVAS ESTRATEGIAS MOLECULARES PARA EL TRATAMIENTO Y DIAGNOSTICO DE CANCERES
dc.relation.publisherversionhttp://dx.doi.org/10.1039/C5SC00295Hgl
dc.rights.accessRightsopen accessgl
dc.subjectAllenamidesgl
dc.subjectCycloadditionsgl
dc.subjectAlkenesgl
dc.subjectAldehydesgl
dc.subjectTetrahydropyransgl
dc.subject.classificationMaterias::Investigación::23 Química::2302 Bioquímicagl
dc.titleGold(I)-catalyzed [2 + 2 + 2] cycloaddition of allenamides, alkenes and aldehydes: a straightforward approach to tetrahydropyransgl
dc.typejournal articlegl
dspace.entity.typePublication
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication.latestForDiscovery5ae222c9-f626-432b-aac5-da78c06ed64f

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