Palladium-Catalyzed Transformations of Alkylidenecyclopropanes

Abstract

Organic synthesis has profoundly impacted fields such as medicinal chemistry, materials science, and agriculture by enabling the creation of complex molecular structures beyond those found in nature. In recent years, the field has embraced sustainable practices aligned with green chemistry principles, prioritizing efficiency, environmental responsibility, and atom economy. In this context, catalysis has emerged as a key synthetic tool, driving more selective and efficient reactions, often under milder conditions, and thereby reducing waste and energy consumption. Among homogeneous catalytic methods, where catalysts and reactants are in the same phase, organometallic complexes featuring transition metals stand out for their tunable electronic and steric properties, which have afforded to broaden significantly the range of achievable chemical transformations, making previously challenging reactions feasible.