Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(III) and Eu(III) ions for specific sensing of a viral RNA

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorPenas Tallón, Cristina
dc.contributor.authorMascareñas Cid, José Luis
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.date.accessioned2017-10-21T12:45:59Z
dc.date.available2017-10-21T12:45:59Z
dc.date.issued2016-01-10
dc.description.abstractRational modification of a natural RNA-binding peptide with a lanthanide EDTA chelator, and a phenanthroline ligand yields a highly selective luminescent sensor. The sensing mechanism relies on the RNA-triggered folding of the peptide into a β-hairpin, which promotes the coordination of the phenanthroline sensitizer, and the efficient sensitization of complexed lanthanide ionsgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipWe are thankful for the support given by the Spanish grants SAF2013-41943-R, CTQ2012-31341, and CTQ2013-49317-EXP, the Xunta de Galicia GRC2013-041, the ERDF, and the European Research Council (Advanced Grant No. 340055). Support of COST Action CM1105, and of the orfeo-cinqa network are kindly acknowledged. C. P. thanks the Spanish MCINN for her PhD fellowship. We would also like to thank Dr Jos´e R. Couceiro (USC) for his help with the RNA transfection experimentsgl
dc.identifier.citationPENAS, CRISTINA, MASCAREÑAS, JOSÉ L. and VÁZQUEZ, M. EUGENIO, 2016, Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(iii) and Eu(iii) ions for specific sensing of a viral RNA. Chem. Sci.. 2016. Vol. 7, no. 4, p. 2674-2678. DOI 10.1039/c5sc04501k. Royal Society of Chemistry (RSC)gl
dc.identifier.doi10.1039/C5SC04501K
dc.identifier.essn2041-6539
dc.identifier.urihttp://hdl.handle.net/10347/15963
dc.language.isoenggl
dc.publisherRoyal Society of Chemistrygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-49317/ES/EXPLORACION DE TERAPIAS ANTITUMORALES ALTERNATIVAS DIRIGIDAS A LAS MITOCONDRIAS
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-41943-R/ES/HERRAMIENTAS SINTETICAS EN QUIMICA BIOLOGICA. NUEVAS ESTRATEGIAS MOLECULARES PARA EL TRATAMIENTO Y DIAGNOSTICO DE CANCERES
dc.relation.publisherversionhttp://dx.doi.org/10.1039/C5SC04501Kgl
dc.rights© 2016 Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution 3.0 Unported Licencegl
dc.rights.accessRightsopen accessgl
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/gl
dc.titleCoupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(III) and Eu(III) ions for specific sensing of a viral RNAgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication34f1e1e8-411b-4b42-a25c-253481d3abef
relation.isAuthorOfPublication.latestForDiscovery5ae222c9-f626-432b-aac5-da78c06ed64f

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