The multifaceted roles of gasdermins in cancer biology and oncologic therapies

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Físicaes_ES
dc.contributor.authorSarrió, David
dc.contributor.authorMartínez-Val, Jeannette
dc.contributor.authorMolina Crespo, Ángela
dc.contributor.authorSánchez Piñón, Laura
dc.contributor.authorMoreno-Bueno, Gema
dc.date.accessioned2024-01-24T14:05:50Z
dc.date.available2024-01-24T14:05:50Z
dc.date.issued2021
dc.description.abstractThe involvement of the Gasdermin (GSDM) protein family in cancer and other pathologies is one of the hottest topics in biomedical research. There are six GSDMs in humans (GSDMA, B, C, D, GSDME/DFNA5 and PJVK/ DFNB59) and, except PJVK, they can trigger cell death mostly by pyroptosis (a form of lytic and proinflammatory cell death) but also other mechanisms. The exact role of GSDMs in cancer is intricate, since depending on the biological context, these proteins have diverse cell-death dependent and independent functions, exhibit either pro-tumor or anti-tumor functions, and promote either sensitization or resistance to oncologic treatments. In this review we provide a comprehensive overview on the multifaceted roles of the GSDMs in cancer, and we critically discuss the possibilities of exploiting GSDM functions as determinants of anti-cancer treatment and as novel therapeutic targets, with special emphasis on innovative GSDM-directed nano-therapies. Finally, we discuss the issues to be resolved before GSDM-mediated oncologic therapies became a reality at the clinical level.es_ES
dc.description.peerreviewedSIes_ES
dc.description.sponsorshipThis study was supported by the Ministerio de Ciencia e Innovación (PID2019-104644RB-I00 -GMB-), the Instituto de Salud Carlos III (CIBERONC, CB16/12/00295 –GMB-; partly supported by FEDER funds) and by the Fundación Científica de la AECC (FC_AECC PROYE19036MOR -GMB-).es_ES
dc.identifier.citationSarrió, D., Martínez-Val, J., Molina-Crespo, Á., Sánchez, L., & Moreno-Bueno, G. (2021). The multifaceted roles of gasdermins in cancer biology and oncologic therapies. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1876(2), 188635es_ES
dc.identifier.doi10.1016/j.bbcan.2021.188635
dc.identifier.issn1879-2561
dc.identifier.urihttp://hdl.handle.net/10347/31975
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104644RB-I00/ES/CARACTERIZACION MOLECULAR DE LA ACTIVIDAD CITOTOXICA DE GASDERMINA B Y SU POTENCIAL APLICACION COMO TRATAMIENTO EN CANCER/es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.bbcan.2021.188635es_ES
dc.rights© 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND licensees_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectGasdermines_ES
dc.subjectPyroptosises_ES
dc.subjectCancer cell deathes_ES
dc.subjectCancer treatmentes_ES
dc.subjectInflammationes_ES
dc.titleThe multifaceted roles of gasdermins in cancer biology and oncologic therapieses_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication017b2725-d3de-40d7-8859-18c50f038d1d
relation.isAuthorOfPublication.latestForDiscovery017b2725-d3de-40d7-8859-18c50f038d1d

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