Study of biomolecular self-assembly and host-guest association using spectroscopic and microscopic techniques

Abstract

Neurodegenerative diseases represent a major health problem. Biomolecules involved in these disorders are essential for life, but the misregulation of their interactions can lead to severe damage it. Thus, understanding these biomolecular interactions is vital for developing effective treatments. In this thesis, we study the self-assembly and binding processes of biomolecules like G-quadruplexes, amyloid peptides, and blood plasma proteins, which are thought to be involved in Alzheimer’s disease. Using microscopic and spectroscopic techniques, we study the mechanisms behind the selfassembly of G-Quadruplexes, the aggregation of amyloid peptides and the host-guest association of blood plasma proteins with fluorescence probes.