Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxíagl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Fisioloxíagl
dc.contributor.authorRubiolo Gaytán, Juan Andrés
dc.contributor.authorTernon, Eva
dc.contributor.authorLópez Alonso, Henar
dc.contributor.authorThomas, Olivier P.
dc.contributor.authorVega Lisi, Félix Víctor
dc.contributor.authorRodríguez Vieytes, Mercedes
dc.contributor.authorBotana López, Luis Miguel
dc.date.accessioned2020-11-09T08:44:34Z
dc.date.available2020-11-09T08:44:34Z
dc.date.issued2013
dc.description.abstractIn this paper, we show the effect of crambescidin-816, -800, and -830 on Saccharomyces cerevisiae viability. We determined that, of the three molecules tested, crambescidin-816 was the most potent. Based on this result, we continued by determining the effect of crambescidin-816 on the cell cycle of this yeast. The compound induced cell cycle arrest in G2/M followed by an increase in cell DNA content and size. When the type of cell death was analyzed, we observed that crambescidin-816 induced apoptosis. The antifungal effect indicates that crambescidins, and mostly crambescidin-816, could serve as a lead compound to fight fungal infectionsgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThe research leading to these results has received funding from the following FEDER cofunded-grants: From Ministerio de Ciencia y Tecnología, Spain: AGL2009-13581-CO2-01, AGL2012-40485-CO2-01. From Xunta de Galicia, Spain: 10PXIB261254 PR. From the European Union’s Seventh Framework Programme managed by REA—Research Executive Agency (FP7/2007-2013) under grant agreement Nos. 211326—CP (CONffIDENCE), 265896 BAMMBO, 265409 µAQUA, and 262649 BEADS, 315285 Ciguatools and 312184 PharmaSea. From the Atlantic Area Programme (Interreg IVB Trans-national): 2009-1/117 Pharmatlanticgl
dc.identifier.citationRubiolo, J.A.; Ternon, E.; López-Alonso, H.; Thomas, O.P.; Vega, F.V.; Vieytes, M.R.; Botana, L.M. Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae. Mar. Drugs 2013, 11, 4419-4434gl
dc.identifier.doi10.3390/md11114419
dc.identifier.essn1660-3397
dc.identifier.urihttp://hdl.handle.net/10347/23606
dc.language.isoenggl
dc.publisherMDPIgl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/265896
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/265409
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/262649
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/315285
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/312184
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN/Plan Nacional de I+D+i 2008-2011/AGL2009-13581-C02-01/ES/Evaluacion De Los Riesgos De Salud Publica Debidos A Toxinas Marinas De Aguas Templadas En Las Costas Europeas Y Del Efecto Sinergico Con Otras Toxinas Habituales En Estas Latitudes. Subproyecto 2
dc.relation.publisherversionhttps://doi.org/10.3390/md11114419gl
dc.rights© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)gl
dc.rights.accessRightsopen accessgl
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectCrambescidine-816gl
dc.subjectAntifungalgl
dc.subjectCell cycle arrestgl
dc.subjectApoptosisgl
dc.titleCrambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiaegl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublication6574bec8-97de-4fab-b2ba-d35b85751f34
relation.isAuthorOfPublication91f88e2e-ed1a-43f4-a16c-8d8d5c998e40
relation.isAuthorOfPublication9a18ed42-77b6-4760-8303-ff4070a87ca6
relation.isAuthorOfPublication.latestForDiscovery6574bec8-97de-4fab-b2ba-d35b85751f34

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