Predicting PSR Filters by Transverse Relaxation Enhancements

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2015_fernandez_analchem_predicting_psr.pdf (1.94 MB)
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URI: http://hdl.handle.net/10347/16950
ISSN: 0003-2700
E-ISSN: 1520-6882
DOI: 10.1021/ac5037186

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2015

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American Chemical Society
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The paramagnetic spin relaxation (PSR) filter allows the suppression of the NMR resonances of individual components in mixtures according to their Gd3+-complexing ability. The difficulty in predicting this property hampers, however, the widespread application of this filter. Herein we describe that the PSR filter is dominated by the transverse relaxation enhancement (R2p) experienced by nuclei in the presence of Gd3+, so that R2p represents a reliable predictive tool of suppression in the 1D and 2D PSR filter of complex mixtures. The robustness of R2p as a predictive tool in PSR filters has been demonstrated at different magnetic fields and for the 1H, 13C, COSY, and HMQC filtering of commercial multicomponent compositions, including beverages and drugs

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Correa, J., Pinto, L., Riguera, R., & Fernandez-Megia, E. (2015). Predicting PSR Filters by Transverse Relaxation Enhancements. Analytical Chemistry, 87(1), 760-767. doi: 10.1021/ac5037186

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This work was financially supported by the Spanish Government (CTQ2012-34790, CTQ2012-33436) and the Xunta de Galicia (CN2011/037). L.F.P. thanks the Portuguese Foundation for Science and Technology (FCT MCTES) for a Ph.D. grant (SFRH/BD/37341/2007)

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© 2015 American Chemical Society

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Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)
Química Orgánica