Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicases_ES
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Ciencias Morfolóxicases_ES
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Fisioloxíaes_ES
dc.contributor.authorMartínez de Morentín, Pablo B.
dc.contributor.authorGonzález García, Ismael
dc.contributor.authorMartins, Luís
dc.contributor.authorLage Fernández, Ricardo
dc.contributor.authorFernández Mallo, Diana
dc.contributor.authorMartínez Sánchez, Noelia
dc.contributor.authorRuíz Pino, Francisco
dc.contributor.authorLiu, Ji
dc.contributor.authorMorgan, Donald A.
dc.contributor.authorPinilla, Leonor
dc.contributor.authorGallego Gómez, María Rosalía
dc.contributor.authorSaha, Asish K.
dc.contributor.authorKalsbeek, Andries
dc.contributor.authorFliers, Eric
dc.contributor.authorBisschop, Peter
dc.contributor.authorDiéguez González, Carlos
dc.contributor.authorNogueiras Pozo, Rubén
dc.contributor.authorRahmouni, Kamal
dc.contributor.authorTena Sempere, Manuel
dc.contributor.authorLópez Pérez, Miguel A.
dc.date.accessioned2024-02-06T13:29:00Z
dc.date.available2024-02-06T13:29:00Z
dc.date.issued2014
dc.description.abstractEstrogens play a major role in the modulation of energy balance through central and peripheral actions. Here, we demonstrate that central action of estradiol (E2) inhibits AMP-activated protein kinase (AMPK) through estrogen receptor alpha (ERα) selectively in the ventromedial nucleus of the hypothalamus (VMH), leading to activation of thermogenesis in brown adipose tissue (BAT) through the sympathetic nervous system (SNS) in a feeding-independent manner. Genetic activation of AMPK in the VMH prevented E2-induced increase in BAT-mediated thermogenesis and weight loss. Notably, fluctuations in E2 levels during estrous cycle also modulate this integrated physiological network. Together, these findings demonstrate that E2 regulation of the VMH AMPK-SNS-BAT axis is an important determinant of energy balance and suggest that dysregulation in this axis may account for the common changes in energy homeostasis and obesity linked to dysfunction of the female gonadal axises_ES
dc.description.peerreviewedSIes_ES
dc.description.sponsorshipThe research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 281854, the ObERStress European Research Council Project (M.L.), and 245009, the Neurofast project (R.N., C.D., and M.L.); Xunta de Galicia (R.N.: EM 2012/039 and 2012-CP069; M.L.: 2012-CP070); Junta de Andalucía (M.T.S.: P08-CVI-03788); Instituto de Salud Carlos III (ISCIII) (M.L.: PI12/01814); MINECO cofunded by the FEDER Program of EU (M.T.S.: BFU2011-25021; R.N.: RyC-2008-02219 and BFU2012-35255; C.D.: BFU2011-29102); KNAW (P.H.B.: CEP-09CDP030); ZonMw (A.K.: TOP91207036); and NIH (K.R.: HL084207). L.M. is a recipient of a fellowship from Fundação para a Ciência e Tecnologia, Portugal (SFRH/BD/65379/2009). I.G.-G. is a recipient of a fellowship from Ministerio de Educación, Cultura y Deporte (FPU12/01827). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIIIes_ES
dc.identifier.citationCell Metabolism. Volume 20, Issue 1, 1 July 2014, Pages 41-53es_ES
dc.identifier.doi10.1016/j.cmet.2014.03.031
dc.identifier.essn1932-7420
dc.identifier.issn1550-4131
dc.identifier.urihttp://hdl.handle.net/10347/32449
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/281854/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/245009/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//BFU2011-25021/ES/PUBERTAD - NUEVOS SISTEMAS DE REGULACION POR NEUROPEPTIDOS Y MICRORNAS, Y SU INTERACCION CON SEÑALES METABOLICAS Y OBESIDAD/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//RYC-2008-02219/ES/RYC-2008-02219/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//BFU2012-35255/ES/PAPEL DE LOS RECEPTORES OPIOIDES COMO MEDIADORES DE LAS ACCIONES NEUROENDOCRINAS DE LA HORMONA CONCENTRADORA DE MELANINA (MCH)/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//BFU2011-29102/ES/REGULACION DE LA INGESTA POR GHRELIN/es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.cmet.2014.03.031es_ES
dc.rights© Elsevier, 2014. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/)es_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.titleEstradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPKes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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