Canonical DNA minor groove insertion of bisbenzamidine–Ru(ii) complexes with chiral selectivity

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Inorgánicagl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorSánchez, Mateo I.
dc.contributor.authorRama, Gustavo
dc.contributor.authorCalo Lapido, Renata
dc.contributor.authorUcar, Kübra
dc.contributor.authorLincoln, Per
dc.contributor.authorVázquez López, Miguel
dc.contributor.authorMelle-Franco, Manuel
dc.contributor.authorMascareñas Cid, José Luis
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.date.accessioned2019-09-30T20:49:39Z
dc.date.available2019-09-30T20:49:39Z
dc.date.issued2019
dc.description.abstractWe report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor groove DNA-binding agent with a ruthenium(II) complex. Importantly, one of the enantiomers (Δ-[Ru(bpy)2b4bpy]2+, Δ-4Ru) shows a considerably higher DNA affinity than the parent organic ligand and the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible lightgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipFinancial support from the Spanish grants CTQ2015-70698-R, SAF2016-76689-R and Orfeo-cinqa network CTQ2016-81797-REDC; the Ministerio de Ciencia, Innovación y Universidades of Spain, RTI2018-099877-B-I00; the Xunta de Galicia (2015-CP082, ED431C 2017/19, Centro singular de investigación de Galicia accreditation 2016–2019, ED431G/09), the European Union (European Regional Development Fund – ERDF), and the European Research Council (Advanced Grant No. 340055) are gratefully acknowledged. We also acknowledge the support from the Portuguese Foundation for Science and Technology, FCT, (IF/00894/2015) and CICECO – Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019, financed by national funds through the FCT/MCTES. M. E. V. also acknowledges the support of the Fundación Asociación Española Contra el Cáncer (AECC) (IDEAS197VAZQ grant)gl
dc.identifier.citationChem. Sci., 2019,10, 8668-8674gl
dc.identifier.doi10.1039/C9SC03053K
dc.identifier.essn2041-6539
dc.identifier.urihttp://hdl.handle.net/10347/19838
dc.language.isoenggl
dc.publisherRoyal Society of Chemistrygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-81797/ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-76689-R/ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-81797-REDC/ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2015-70698-R/ES/SISTEMAS SUPRAMOLECULARES PARA RECONOCIMIENTO BIOMOLECULAR: HELICATOS PEPTIDICOS Y RECEPTORES OLIGOMERICOS AUTOENSAMBLADOS
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099877-B-I00/ES/PLATAFORMAS PEPTIDICAS PARA APLICACIONES EN QUIMICA (BIO)SUPRAMOLECULAR Y DE MATERIALES, CATALISIS Y SENSORES (SWISSKNIFE)
dc.relation.publisherversionhttps://doi.org/10.1039/C9SC03053Kgl
dc.rightsOpen Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licencegl
dc.rights.accessRightsopen accessgl
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/
dc.titleCanonical DNA minor groove insertion of bisbenzamidine–Ru(ii) complexes with chiral selectivitygl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublication49ee56a2-7094-407b-8108-b55c5968f241
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication34f1e1e8-411b-4b42-a25c-253481d3abef
relation.isAuthorOfPublication.latestForDiscovery49ee56a2-7094-407b-8108-b55c5968f241

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