New nitrogen compounds coupled to phenolic units with antioxidant and antifungal activities: synthesis and structure–activity relationship

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicasgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéuticagl
dc.contributor.authorBettencourt, Ana
dc.contributor.authorCastro Pérez, María de los Ángeles
dc.contributor.authorSilva, João
dc.contributor.authorFernandes, Francisco
dc.contributor.authorCoutinho, Olga
dc.contributor.authorSousa, M. João
dc.contributor.authorProença, M. Fernanda
dc.contributor.authorAreias, Filipe
dc.date.accessioned2020-05-24T18:13:13Z
dc.date.available2020-05-24T18:13:13Z
dc.date.issued2018
dc.description.abstractA selection of 1-amino-2-arylidenamine-1,2-(dicyano)ethenes 3 was synthesized and cyclized to 2-aryl-4,5-dicyano-1H-imidazoles 4 upon reflux in ethyl acetate/acetonitrile, in the presence of manganese dioxide. These compounds were tested for their antioxidant capacity by cyclic voltammetry, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and deoxyribose degradation assays. The minimum inhibitory concentration of all compounds was evaluated against two yeast species, Saccharomyces cerevisiae and Candida albicans. Their toxicity was tested in mammal fibroblasts. Among the synthesised compounds, two presented dual antioxidant/antifungal activity without toxic effects in fibroblasts. The new compounds synthesized in this work are potential biochemical tools and/or therapeutic drugsgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThis research was funded by the Portuguese Fundação para a Ciência e Tecnologia (PPCDT/QUI/59356). Filipe Areias gratefully acknowledges a post-PhD grant from the Portuguese FCT (SFRH/BPD/26106)gl
dc.identifier.citationBettencourt, A.; Castro, M.; Silva, J.; Fernandes, F.; Coutinho, O.; Sousa, M.J.; Proença, M.F.; Areias, F. New Nitrogen Compounds Coupled to Phenolic Units with Antioxidant and Antifungal Activities: Synthesis and Structure–Activity Relationship. Molecules 2018, 23, 2530gl
dc.identifier.doi10.3390/molecules23102530
dc.identifier.essn1420-3049
dc.identifier.urihttp://hdl.handle.net/10347/22506
dc.language.isoenggl
dc.publisherMDPIgl
dc.relation.publisherversionhttps://doi.org/10.3390/molecules23102530gl
dc.rights© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)gl
dc.rights.accessRightsopen accessgl
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectImidazolesgl
dc.subjectPhenolic compoundsgl
dc.subjectAntifungal activitygl
dc.subjectMICgl
dc.subjectAntioxidant capacitygl
dc.subjectStructure-activity relationshipgl
dc.titleNew nitrogen compounds coupled to phenolic units with antioxidant and antifungal activities: synthesis and structure–activity relationshipgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublication3324fbd0-3052-423e-a32e-b6076649d041
relation.isAuthorOfPublication.latestForDiscovery3324fbd0-3052-423e-a32e-b6076649d041

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