Palladium-Catalyzed [5 + 2] Rollover Annulation of 1-Benzylpyrazoles with Alkynes: A Direct Entry to Tricyclic 2-Benzazepines

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorSuárez Lustres, Alejandro
dc.contributor.authorMartínez Yáñez, Nuria
dc.contributor.authorVelasco Rubio, Álvaro
dc.contributor.authorVarela Carrete, Jesús Ángel
dc.contributor.authorSaá Rodríguez, Carlos
dc.date.accessioned2023-03-17T07:31:02Z
dc.date.available2023-03-17T07:31:02Z
dc.date.issued2023
dc.description.abstractThe first Pd-catalyzed [5 + 2] rollover annulation of 1-benzylpyrazoles with alkynes to assemble 10H-benzo[e]pyrazolo[1,5-a]azepines (tricyclic 2-benzazepines) has been developed. The rollover annulation implies a twofold C–H activation of aryl and heteroaryl Csp2–H bonds (C–H/C–H) of 1-benzylpyrazoles (five-atom partners) and alkynes to give the [5 + 2] annulated compounds.gl
dc.description.peerreviewedSIgl
dc.description.sponsorshipWe acknowledge financial support from MICINN (Project PID2020-118048GB-I00 and ORFEO−CINQA Network RED2018-102387-T), the Xunta de Galicia (Project ED431C 2022/27 and Centro Singular de Investigación de Galicia Accreditation 2019−2022, ED431G 2019/03), and the European Union (European Regional Development Fund). A.S.-L. thanks MICINN for a predoctoral contract.gl
dc.identifier.citationSuárez-Lustres, A., Martínez-Yáñez, N., Velasco-Rubio, A., Varela, J. A., Saá, C. (2023). Palladium-Catalyzed [5 + 2] Rollover Annulation of 1-Benzylpyrazoles with Alkynes: A Direct Entry to Tricyclic 2-Benzazepines. Org. Lett., 25, 5, 794-799gl
dc.identifier.doi10.1021/acs.orglett.2c04300
dc.identifier.essn1523-7052
dc.identifier.issn1523-7060
dc.identifier.urihttp://hdl.handle.net/10347/30335
dc.language.isoenggl
dc.publisherAmerican Chemical Societygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118048GB-I00/ESgl
dc.relation.publisherversionhttps://doi.org/10.1021/acs.orglett.2c04300gl
dc.rights© 2023 American Chemical Society. This is an open access article under the CC Attribution 4.0 International (CC BY 4.0) license (http://creativecommons.org/licenses/by/4.0/)gl
dc.rights.accessRightsopen accessgl
dc.subjectAnnulationsgl
dc.subject2-Benzazepinesgl
dc.subjectCyclizationgl
dc.subjectPalladium catalystgl
dc.titlePalladium-Catalyzed [5 + 2] Rollover Annulation of 1-Benzylpyrazoles with Alkynes: A Direct Entry to Tricyclic 2-Benzazepinesgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublicatione9be05f9-b5a3-405c-aaf6-4e32700dd21d
relation.isAuthorOfPublication2c024eb2-7698-4785-bd0c-518f70068330
relation.isAuthorOfPublication.latestForDiscoverye9be05f9-b5a3-405c-aaf6-4e32700dd21d

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