Yessotoxin, a promising therapeutic tool

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéuticagl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Fisioloxíagl
dc.contributor.authorAlfonso Rancaño, María Amparo
dc.contributor.authorRodríguez Vieytes, Mercedes
dc.contributor.authorBotana López, Luis Miguel
dc.date.accessioned2017-10-20T16:34:09Z
dc.date.available2017-10-20T16:34:09Z
dc.date.issued2016-01-28
dc.description.abstractYessotoxin (YTX) is a polyether compound produced by dinoflagellates and accumulated in filter feeding shellfish. No records about human intoxications induced by this compound have been published, however it is considered a toxin. Modifications in second messenger levels, protein levels, immune cells, cytoskeleton or activation of different cellular death types have been published as consequence of YTX exposure. This review summarizes the main intracellular pathways modulated by YTX and their pharmacological and therapeutic implicationsgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThe research leading to these results has received funding from the following FEDER cofunded grants. From CDTI and Technological Funds, supported by Ministerio de Economía y Competitividad, AGL2012-40185-CO2-01, AGL2014-58210-R; Consellería de Cultura, Educación e Ordenación Universitaria, GRC2013-016; CDTI under ISIP Programme, Spain, IDI-20130304 APTAFOOD; and the European Union’s Seventh Framework Programme managed by REA—Research Executive Agency (FP7/2007–2013) under grant agreement 312184 PHARMASEAgl
dc.identifier.citationAlfonso, A.; Vieytes, M.R.; Botana, L.M. Yessotoxin, a Promising Therapeutic Tool. Mar. Drugs 2016, 14, 30gl
dc.identifier.doi10.3390/md14020030
dc.identifier.essn1660-3397
dc.identifier.urihttp://hdl.handle.net/10347/15901
dc.language.isoenggl
dc.publisherMDPIgl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/312184
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-58210-R/ES/EVALUACION DE LA SEGURIDAD ALIMENTARIA DE PRODUCTOS PESQUEROS ASOCIADA A LA PRESENCIA DE TOXINAS MARINAS DE NUEVA APARICION EN AGUAS EUROPEAS
dc.relation.publisherversionhttps://doi.org/10.3390/md14020030gl
dc.rights© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/)gl
dc.rights.accessRightsopen accessgl
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectYessotoxin (YTX)gl
dc.subjectApoptosisgl
dc.subjectAutophagygl
dc.subjectCellular deathgl
dc.subjectSignal transductiongl
dc.subjectCytoskeletongl
dc.subjectImmune systemgl
dc.subjectAlzheimergl
dc.subjectGlucose metabolismgl
dc.titleYessotoxin, a promising therapeutic toolgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublicatione493d380-66bb-4ff9-bb05-4da21d0b21e7
relation.isAuthorOfPublication91f88e2e-ed1a-43f4-a16c-8d8d5c998e40
relation.isAuthorOfPublication9a18ed42-77b6-4760-8303-ff4070a87ca6
relation.isAuthorOfPublication.latestForDiscoverye493d380-66bb-4ff9-bb05-4da21d0b21e7

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