Chain-branched polyhydroxylated Octahydro-1H-Indoles as potential leads against lysosomal storage diseases

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánica
dc.contributor.authorEstévez Cabanas, Juan Carlos
dc.contributor.authorGonzález, Marcos A.
dc.contributor.authorVillaverde Cameron-Walker, María del Carmen
dc.contributor.authorHirokami, Yuki
dc.contributor.authorKato, Atsushi
dc.contributor.authorSussman, Fredy Salomon
dc.contributor.authorReza Ramos, David
dc.contributor.authorEstévez Cabanas, Ramón José
dc.date.accessioned2020-04-10T10:16:51Z
dc.date.available2020-04-10T10:16:51Z
dc.date.issued2019
dc.description.abstractHere, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) acetaldehydes, followed by a protocol involving the formation of the azacyclopentane ring. Results of inhibitory potency assays and docking calculations show that at least one of them could be a lead for optimization in the search for compounds that behave like folding chaperones in lysosomal storage diseasesgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipThis work has received financial support from the Spanish Ministry of Science and Innovation (CTQ2009-08490), the Xunta de Galicia (Centro Singular de Investigación de Galicia, accreditation 2016–2019, ED431B 2018/13; Project CN2011/037 and Project GRC2014/040), and the European Union (European Regional Development Fund-ERDF). It has also received a Grant-in-Aid for Scientific Research (C) from the Japanese Society for the Promotion of Science (JSPS KAKENHI Grant Number JP17K08362) (AK)gl
dc.identifier.citationEstévez, J.C.; González, M.A.; Villaverde, M.C.; Hirokami, Y.; Kato, A.; Sussman, F.; Reza, D.; Estévez, R.J. Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases. Pharmaceuticals 2019, 12, 47gl
dc.identifier.doi10.3390/ph12020047
dc.identifier.essn1424-8247
dc.identifier.urihttp://hdl.handle.net/10347/21304
dc.language.isoenggl
dc.publisherMDPIgl
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN/Plan Nacional de I+D+i 2008-2011/CTQ2009-08490/ES
dc.relation.publisherversionhttps://doi.org/10.3390/ph12020047gl
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)gl
dc.rights.accessRightsopen accessgl
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectSugarsgl
dc.subjectIminosugarsgl
dc.subjectGlycosidase inhibitiongl
dc.titleChain-branched polyhydroxylated Octahydro-1H-Indoles as potential leads against lysosomal storage diseasesgl
dc.typejournal articlegl
dc.type.hasVersionVoRgl
dspace.entity.typePublication
relation.isAuthorOfPublication86b5b898-6642-4dd7-b2ee-117e2f4838ff
relation.isAuthorOfPublicatione81f6777-aab2-46ab-9bbe-808c4f00a9df
relation.isAuthorOfPublication19cdf079-dc1b-48b2-8bc9-c73d3601f141
relation.isAuthorOfPublication.latestForDiscovery86b5b898-6642-4dd7-b2ee-117e2f4838ff

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