Assembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT‐Hook Adaptor

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorLearte Aymamí, Soraya
dc.contributor.authorRodríguez Villar, Jéssica
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2020-07-24T11:56:50Z
dc.date.available2021-04-01T01:00:12Z
dc.date.issued2020
dc.description.abstractThe nickel(II)‐mediated self‐assembly of a multimeric DNA binder is described. The binder is composed of two metal‐chelating peptides derived from a bZIP transcription factor (brHis2) and one short AT‐hook domain equipped with two bipyridine ligands (HkBpy2). These peptides reversibly assemble in the presence of NiII ions at selected DNA sequences of 13 base pairsgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipFinancial support from the Spanish grants SAF2016‐76689‐R, RTI2018‐099877‐B‐I00, Orfeo‐cinqa network CTQ2016‐81797‐REDC, the Xunta de Galicia (2015‐CP082, ED431C‐2017/19 and Centro Singular de Investigación de Galicia accreditation 019–2022, ED431G 2019/03), the European Union (European Regional Development Fund—ERDF), and the European Research Council (Advanced Grant No. 340055) are gratefully acknowledged. S.L.‐A. thanks the Spanish MINECO for her FPI fellowship (BES‐2017‐080555); J.R. thanks the Xunta de Galicia for her PhD fellowshipgl
dc.identifier.citationS. Learte-Aymamí, J. Rodríguez, M. E. Vázquez, J. L. Mascareñas, Chem. Eur. J. 2020 , 26 , 8875.gl
dc.identifier.doi10.1002/chem.202001277
dc.identifier.essn1521-3765
dc.identifier.issn0947-6539
dc.identifier.urihttp://hdl.handle.net/10347/23208
dc.language.isoenggl
dc.publisherWileygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016‐76689‐R/ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018‐099877‐B‐I00/ES/PLATAFORMAS PEPTIDICAS PARA APLICACIONES EN QUIMICA (BIO)SUPRAMOLECULAR Y DE MATERIALES, CATALISIS Y SENSORES (SWISSKNIFE)
dc.relation.publisherversionhttps://doi.org/10.1002/chem.202001277gl
dc.rights© 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versionsgl
dc.rights.accessRightsopen accessgl
dc.subjectChemical biologygl
dc.subjectDNA bindinggl
dc.subjectMolecular recognitiongl
dc.subjectPeptidesgl
dc.subjectSupramolecular chemistrygl
dc.titleAssembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT‐Hook Adaptorgl
dc.typejournal articlegl
dc.type.hasVersionAMgl
dspace.entity.typePublication
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