Reversible supramolecular assembly at specific DNA sites: Ni-promoted, bivalent DNA binding with designed peptide and bipyridylbisbenzamidine components

Simple item page
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorSánchez López, Mateo Isidro
dc.contributor.authorMosquera Mosquera, Jesús
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorMascareñas Cid, José Luis
dc.date.accessioned2014-12-05T11:53:22Z
dc.date.available2017-08-29T01:00:16Z
dc.date.issued2014-07-15
dc.description.abstractAt specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA-binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility.gl
dc.description.peerreviewedSIgl
dc.description.sponsorshipWe are thankful for support from Spanish grants (SAF2010-20822-C02 and CTQ2012-31341), Consolider Ingenio 2010 (CSD2007-00006), the Xunta de Galicia (GRC2013-041, INCITE09 209084PR, and PGIDIT08CSA-047209PR), the ERDF, and the European Research Council (Advanced Grant 340055). J.M. and M.I.S. thank the Spanish MCINN for their Ph.D. fellowships.gl
dc.identifier.citationSánchez, M. I., Mosquera, J., Vázquez, M. E. and Mascareñas, J. L. (2014), Reversible Supramolecular Assembly at Specific DNA Sites: Nickel-Promoted Bivalent DNA Binding with Designed Peptide and Bipyridyl–Bis(benzamidine) Components. Angew. Chem. Int. Ed., 53: 9917–9921. doi: 10.1002/anie.201405726gl
dc.identifier.doi10.1002/anie.201405726
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/10347/11965
dc.language.isoenggl
dc.publisherWILEY-VCH Verlag GmbHgl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.publisherversionhttp://dx.doi.org/10.1002/anie.201405726gl
dc.rights© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimgl
dc.rights.accessRightsopen accessgl
dc.subjectDNA recognitiongl
dc.subjectMinor-groove bindersgl
dc.subjectPeptidesgl
dc.subjectSelf-assemblygl
dc.subjectSupramolecular chemistrygl
dc.subject.classificationMaterias::Investigación::23 Química::2302 Bioquímicagl
dc.titleReversible supramolecular assembly at specific DNA sites: Ni-promoted, bivalent DNA binding with designed peptide and bipyridylbisbenzamidine componentsgl
dc.typejournal articlegl
dc.type.hasVersionAMgl
dspace.entity.typePublication
relation.isAuthorOfPublication34f1e1e8-411b-4b42-a25c-253481d3abef
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication.latestForDiscovery34f1e1e8-411b-4b42-a25c-253481d3abef

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Reversible_Supramolecular_Assembly_at_Specific_DNA_Sites.pdf
Size:
815.47 KB
Format:
Adobe Portable Document Format
Download

Collections

Centro de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)
Química Orgánica