Neurotoxicity Induced by Oxidative Stress and Aluminium in Relation to Parkinson’s Disease: A Mitochondrial Bioenergetic Approach by High‐Resolution Respirometry

Abstract

The study of mitochondria during the last years has revealed that this organelle plays an important role in the development and onset of neurodegenerative disorders such as Parkinson’s disease. The main hallmarks found in post‐mortem studies remark the importance of brain free radicals levels, the alteration in brain metabolic parameters and the presence of xenobiotics like metals for the neurodegenerative processes. Also, any energetic deficit related with the metabolic impairment due to an exposition to toxics or an increase in oxidative stress might be a favorable condition for the onset of Parkinson’s disease. Within this framework, and in order to gain insight in the aetiology of Parkinson’s disease, this Thesis was developed as a bioenergetics study focused to oxidative stress, Parkinson’s disease, and aluminium.