Synergistic gold and enamine catalysis: intermolecular α-alkylation of aldehydes with allenamides

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.authorFernández Casado, Jaime
dc.contributor.authorNelson, Ronald
dc.contributor.authorMascareñas Cid, José Luis
dc.contributor.authorLópez García, Fernando
dc.date.accessioned2016-04-04T12:52:55Z
dc.date.available2017-08-29T01:00:16Z
dc.date.issued2016-01-08
dc.descriptionNOTICE: This is the peer reviewed version of the following article: Jaime Fernández-Casado, Ronald Nelson, José L. Mascareñas* and Fernando López* (2016), Synergistic Gold and Enamine Catalysis: Intermolecular α-Alkylation of Aldehydes with Allenamides. ChemComm., 52, 2909-2912 [10.1039/C5CC09533F]. This article may be used for non-commercial purposes in accordance with RSC Terms and Conditions for self-archivinggl
dc.description.abstractAldehydes can be α-alkylated with allenamides by the combined action of an organocatalyst and a gold complex. The reaction requires the simultaneous generation of an enamine and a gold-activated allenamide. Importantly, by using a chiral amine as organocatalyst it is possible to obtain aldehyde products featuring all-carbon quaternary stereocenter at their α-position, with moderate to good levels of enantioselectivitygl
dc.description.sponsorshipThis work was supported by the Spanish MINECO (SAF2013-41943-R), the ERDF, the European Research Council (Adv. Grant No. 340055) and the Xunta de Galicia (GRC2013-041)gl
dc.identifier.citationFernández-Casado, J., Nelson, R., Mascareñas, J.L. and López, F. (2016), Synergistic gold and enamine catalysis: intermolecular α-alkylation of aldehydes with allenamides. Chem. Commun., 52, 2909-2912 [DOI:10.1039/C5CC09533F]gl
dc.identifier.doi10.1039/C5CC09533F
dc.identifier.issn1359-7345
dc.identifier.otherE-ISSN 1364-548X
dc.identifier.urihttp://hdl.handle.net/10347/14565
dc.language.isoenggl
dc.publisherRoyal Society of Chemistrygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-41943-R/ES/HERRAMIENTAS SINTETICAS EN QUIMICA BIOLOGICA. NUEVAS ESTRATEGIAS MOLECULARES PARA EL TRATAMIENTO Y DIAGNOSTICO DE CANCERES
dc.relation.publisherversionhttp://dx.doi.org/10.1039/C5CC09533Fgl
dc.rights.accessRightsopen accessgl
dc.subjectAldehydesgl
dc.subjectAllenamidesgl
dc.subjectEnantioselectivitygl
dc.subjectGold complexgl
dc.subjectOrganocatalystgl
dc.subject.classificationMaterias::Investigación::23 Químicagl
dc.titleSynergistic gold and enamine catalysis: intermolecular α-alkylation of aldehydes with allenamidesgl
dc.typejournal articlegl
dspace.entity.typePublication
relation.isAuthorOfPublication5ae222c9-f626-432b-aac5-da78c06ed64f
relation.isAuthorOfPublication.latestForDiscovery5ae222c9-f626-432b-aac5-da78c06ed64f

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