The Complexity of TET2 Functions in Pluripotency and Development

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Fisioloxía
dc.contributor.authorGarcía Outeiral, Vera
dc.contributor.authorParte, Cristina de la
dc.contributor.authorFidalgo Pérez, Miguel Ángel
dc.date.accessioned2025-01-17T12:50:44Z
dc.date.available2025-01-17T12:50:44Z
dc.date.issued2021-01-18
dc.description.abstractTen-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of biological processes, including embryonic development and tissue homeostasis. TET2 catalyzes the demethylation of 5-methylcytosine on DNA, affecting transcriptional regulation. New exciting research has provided evidence for TET2 catalytic activity in post-transcriptional regulation through RNA hydroxymethylation. Here we review the current understanding of TET2 functions on both DNA and RNA, and the influence of these chemical modifications in normal development and pluripotency contexts, highlighting TET2 versatility in influencing genome regulation and cellular phenotypes
dc.description.peerreviewedSI
dc.identifier.citationGarcia-Outeiral V, de la Parte C, Fidalgo M and Guallar D (2021) The Complexity of TET2 Functions in Pluripotency and Development. Front. Cell Dev. Biol. 8:630754. doi: 10.3389/fcell.2020.630754
dc.identifier.doi10.3389/fcell.2020.630754
dc.identifier.essn2296-634X
dc.identifier.urihttps://hdl.handle.net/10347/38662
dc.journal.titleFrontiers in Cell and Developmental Biology
dc.language.isoeng
dc.page.final9
dc.page.initial1
dc.publisherFrontiers
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-096708-J-I00/ES/IMPACTO DE LA MODIFICACION HM5C DEL ARN EN EL ENVEJECIMIENTO Y EL REJUVENECIMIENTO/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105739GB-I00/ES/IMPACTO DEL METABOLISMO Y ENVEJECIMIENTO EN PLURIPOTENCIA A TRAVES DE LA REGULACION EPIGENETICA/
dc.relation.publisherversionhttps://doi.org/10.3389/fcell.2020.630754
dc.rights© 2021 Garcia-Outeiral, de la Parte, Fidalgo and Guallar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTET2
dc.subjectEpigenetic
dc.subjectEpitranscriptomic
dc.subjectPluripotency
dc.subjectReprogramming
dc.subjectDevelopment
dc.subject5hmC
dc.subject.classification32 Ciencias médicas
dc.titleThe Complexity of TET2 Functions in Pluripotency and Development
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number8
dspace.entity.typePublication
relation.isAuthorOfPublicationc2e8c7dd-5b10-4a18-916d-eed1c5831aff
relation.isAuthorOfPublication.latestForDiscoveryc2e8c7dd-5b10-4a18-916d-eed1c5831aff

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