Multi-analyte method for the quantification of bisphenol related compounds in canned food samples and exposure assessment of the Spanish adult population

Abstract

Major types of internal can coatings used for food and beverages are made from synthetic polymers known as epoxy-based resins, mainly based on bisphenol A diglycidyl ether (BADGE). The migration of components from coatings to food is a concern for food safety. A multiresidue method was developed for the identification and quantification of six bisphenols, BADGE and its derivatives, and cyclo-di-BADGE in sixteen canned food samples based on HPLC-FLD. The method developed showed excellent validation data with an adequate linearity, low detection levels, good repeatability and acceptable recoveries. Confirmation of the obtained results was made by LC–MS/MS. The exposure of the adult population to these compounds through the consumption of canned food was assessed. In general, the results suggested a low dietary exposure to this type of compounds (0.003 to 0.985 μg/kg bw/day) with values lower than the established tolerable day intake (TDI). The highest mean concentration was observed for cyclo-di-BADGE in a sample of pickled mussels