Towards personalized medicine in antifungal treatment: combination of pharmacogenetics and pharmacokinetics
| dc.contributor.advisor | Lamas Díaz, María Jesús | |
| dc.contributor.advisor | Fernández Ferreiro, Anxo | |
| dc.contributor.advisor | Campos Toimil, Manuel | |
| dc.contributor.affiliation | Universidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS) | |
| dc.contributor.affiliation | Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde | |
| dc.contributor.author | Blanco Dorado, Sara | |
| dc.date.accessioned | 2020-09-25T11:08:56Z | |
| dc.date.available | 2021-06-05T01:00:10Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Voriconazole is an antifungal agent used in aspergillosis and in fluconazole-resistant Candida spp. infections. Voriconazol is mainly metabolized by cytochrome 2C19 wich is highly polymorphic. A significant portion of patients fail to achieve therapeutic drug concentrations, with a consequently increased risk of therapeutic failure. In this work, the use of voriconazole in the real life clinical setting was studied and a HPLC method for the pharmacokinetic determination of voriconazole was developed. In addition, the factors of voriconazole pharmacokinetic variability were evaluated demonstrating the importance of CYP2C19 pharmacogenetics and pharmacokinetic drug-drug interactions. | gl |
| dc.description.programa | Universidade de Santiago de Compostela. Programa de Doutoramento en Investigación e Desenvolvemento de Medicamentos | |
| dc.identifier.uri | http://hdl.handle.net/10347/23302 | |
| dc.language.iso | eng | gl |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | |
| dc.rights.accessRights | open access | gl |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Voriconazol | gl |
| dc.subject | Farmacogenética | gl |
| dc.subject | Farmacocinética | gl |
| dc.subject | Medicina personalizada | gl |
| dc.subject.classification | Materias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320809 Procesos metabólicos de los medicamentos | gl |
| dc.subject.classification | Materias::Investigación::32 Ciencias médicas::3209 Farmacología | gl |
| dc.title | Towards personalized medicine in antifungal treatment: combination of pharmacogenetics and pharmacokinetics | gl |
| dc.type | doctoral thesis | gl |
| dspace.entity.type | Publication | |
| relation.isAdvisorOfPublication | 0def127e-ecd3-43cc-89ed-13a31e449090 | |
| relation.isAdvisorOfPublication.latestForDiscovery | 0def127e-ecd3-43cc-89ed-13a31e449090 |
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