Motion, fixation probability and the choice of an evolutionary process

Abstract

Seemingly minor details of mathematical and computational models of evolution are known to change the effect of population structure on the outcome of evolutionary processes. For example, birth-death dynamics often result in amplification of selection, while death-birth processes have been associated with suppression. In many biological populations the interaction structure is not static. Instead, members of the population are in motion and can interact with different individuals at different times. In this work we study populations embedded in a flowing medium; the interaction network is then time dependent. We use computer simulations to investigate how this dynamic structure affects the success of invading mutants, and compare these effects for different coupled birth and death processes. Specifically, we show how the speed of the motion impacts the fixation probability of an invading mutant. Flows of different speeds interpolate between evolutionary dynamics on fixed heterogeneous graphs and well-stirred populations; this allows us to systematically compare against known results for static structured populations. We find that motion has an active role in amplifying or suppressing selection by fragmenting and reconnecting the interaction graph. While increasing flow speeds suppress selection for most evolutionary models, we identify characteristic responses to flow for the different update rules we test. In particular we find that selection can be maximally enhanced or suppressed at intermediate flow speedsAuthor summary: Whether a mutation spreads in a population or not is one of the most important questions in biology. The evolution of cancer and antibiotic resistance, for example, are mediated by invading mutants. Recent work has shown that population structure can have important consequences for the outcome of evolution. For instance, a mutant can have a higher or a lower chance of invasion than in unstructured populations. These effects can depend on seemingly minor details of the evolutionary model, such as the order of birth and death events. Many biological populations are in motion, for example due to external stirring. Experimentally this is known to be important; the performance of mutants in E. coli populations, for example, depends on the rate of mixing. Here, we focus on simulations of populations in a flowing medium, and compare the success of a mutant for different flow speeds. We contrast different evolutionary models, and identify what features of the evolutionary model affect mutant success for different speeds of the flow. We find that the chance of mutant invasion can be at its highest (or lowest) at intermediate flow speeds, depending on the order in which birth and death events occur in the evolutionary process