Toxicological studies with cells

Abstract

Cell culture provides a model system that provides direct access and evaluation of the effects of chemicals on tissues and constitutes a valuable tool to analyze cell toxicity mechanisms. In vitro model systems, in general, have been used to study the mechanism of action of chemical and to analyze the cellular basis for chemicals-induced toxicity as well as to develop rapid and high throughput screening systems for the evaluation of the toxicity of chemicals, which may complement in vivo toxicity testing or may replace some in vivo models if scientifically validated and accepted by regulatory agencies.