Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

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dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Orgánicagl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Inorgánicagl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Bioquímica e Bioloxía Moleculargl
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Molecularesgl
dc.contributor.authorBouzada Reboredo, David
dc.contributor.authorSalvadó, Iria
dc.contributor.authorBarka, Ghofrane
dc.contributor.authorRama, Gustavo
dc.contributor.authorMartínez Costas, José Manuel
dc.contributor.authorLorca, Romina
dc.contributor.authorSomoza, Álvaro
dc.contributor.authorMelle-Franco, Manuel
dc.contributor.authorVázquez Sentís, Marco Eugenio
dc.contributor.authorVázquez López, Miguel
dc.date.accessioned2018-07-13T12:45:48Z
dc.date.available2018-12-21T02:00:09Z
dc.date.issued2018
dc.description.abstractA set of Ru(II) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex structures over those lacking it, and also that the interplay between the octoarginine functionalization and the ancillary ligand in the complex has an essential role in the recognition process. Furthermore, the oligoarginine metallopeptides are also efficiently internalized, causing cell death with signs of apoptosisgl
dc.description.peerreviewedSIgl
dc.description.sponsorshipFinancial support from the Spanish grants CTQ2015-70698-R, BFU2013-43513-R and SAF2014-56763-R, the Xunta de Galicia Centro Singular de Investigacion de Galicia accreditation 2016–2019.CICECO – Aveiro Institute of Materials, POCI-01-0145-FEDER007679 (UID/CTM/50011/2013), the UE ERDF and the Fundación AECC (IDEAS197VAZQ-Singulares 2014), are acknowledgedgl
dc.identifier.citationBouzada, D., Salvadó, I., Barka, G., Rama, G., Martínez-Costas, J., & Lorca, R. et al. (2018). Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides. Chemical Communications, 54(6), 658-661. doi: 10.1039/c7cc08286jgl
dc.identifier.doi10.1039/C7CC08286J
dc.identifier.essn1364-548X
dc.identifier.issn1359-7345
dc.identifier.urihttp://hdl.handle.net/10347/17024
dc.language.isoenggl
dc.publisherRoyal Society of Chemistrygl
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-43513-R/ES/REOVIRUS AVIAR: FACTORES DE VIRULENCIA Y NUEVAS DIANAS TERAPEUTICAS
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2015-70698-R/ES/SISTEMAS SUPRAMOLECULARES PARA RECONOCIMIENTO BIOMOLECULAR: HELICATOS PEPTIDICOS Y RECEPTORES OLIGOMERICOS AUTOENSAMBLADOS
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-56763-R/ES/DISEÑO Y EVALUACION DE AGENTES TERAPEUTICOS Y SENSORES BASADOS EN ARNS NO CODIFICANTES Y NANOESTRUCTURAS
dc.relation.publisherversionhttps://doi.org/10.1039/C7CC08286Jgl
dc.rights© The Royal Society of Chemistry 2018gl
dc.rights.accessRightsopen accessgl
dc.titleSelective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptidesgl
dc.typejournal articlegl
dc.type.hasVersionAMgl
dspace.entity.typePublication
relation.isAuthorOfPublicationf55dab55-97e6-4c7d-9b63-71097cbf7aa4
relation.isAuthorOfPublication34f1e1e8-411b-4b42-a25c-253481d3abef
relation.isAuthorOfPublication49ee56a2-7094-407b-8108-b55c5968f241
relation.isAuthorOfPublication.latestForDiscoveryf55dab55-97e6-4c7d-9b63-71097cbf7aa4

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